17667-32-2

Basic information

• Product Name: Methyl-2-bromo-4,5-dimethoxybenzoate
• Synonyms: Methyl-2-bromo-4,5-dimethoxybenzoate;Benzoic acid, 2-bromo-4,5-dimethoxy-, methyl ester
• CAS NO: 17667-32-2
• Molecular Formula: C₁₀H₁₁BrO₄
• Molecular Weight: 275.09594
• Mol File: 17667-32-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 86-88 °C
• Boiling Point: 325.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.436±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• CAS DataBase Reference: Methyl-2-bromo-4,5-dimethoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-2-bromo-4,5-dimethoxybenzoate(17667-32-2)
• EPA Substance Registry System: Methyl-2-bromo-4,5-dimethoxybenzoate(17667-32-2)

Safety Data

• Hazardous Substances Data: 17667-32-2(Hazardous Substances Data)

Usage

Uses

Methyl 2-Bromo-4,5-Dimethoxybenzoate can be used as SOS1 inhibitors.

Upstream product

• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 77-78-1 dimethyl sulfate 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 90050-65-0 2-Bromo-4-hydroxy-5-methoxybenzoic acid 
• 74-88-4 methyl iodide 
• 26759-46-6 methyl 2-amino-4,5-dimethoxybenzoate 
• 186581-53-3 diazomethane 
• 26791-93-5 methyl 4,5-dimethoxy-2-nitrobenzoate 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 

Downstream Products

• 859739-55-2 4,5-dimethoxy-2-phenoxy-benzoic acid methyl ester 
• 2221-50-3 4,5-dimethoxy-2-(2-methoxy-phenoxy)-benzoic acid 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 110815-80-0 tetrahydroisoquinoline 
• 1201566-87-1 C₁₉H₁₆N₂O₆ 
• 1201566-89-3 2-(5-nitroisoquinolin-6-yl)-4,5-dimethoxybenzoic acid methyl ester 
• 1201566-80-4 2-pinacolboranyl-4,5-dimethoxybenzoic acid methyl ester 
• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 6683-58-5 4,5-dimethoxy-2-(4-methoxy-benzoyl)-benzoic acid methyl ester 
• 4191-17-7 5,6-dimethoxy-2- methyl-2,3-dihydro-1H-inden-1-one 
• 52050-44-9 5-methyl-8,9-dimethoxy-6(5H)-phenanthridone 

Relevant articles and documents

Comparative study of the Kumada, Negishi, Stille, and Suzuki - Miyaura reactions in the synthesis of the indole alkaloids hippadine and pratosine

The total synthesis of hippadine by a tandem metalation/cross-coupling/ lactamization strategy was investigated starting from either 7-bromoindole or a 6-halogenated methyl piperonate. The Kumada and Negishi cross-coupling reactions failed to provide any of the desired product. However, the Stille and Suzuki reactions furnished hippadine in low yields starting from the electron-deficient methyl 6-iodo- and 6-bromopiperonate, respectively. Starting from the metalated indole, only the Suzuki reaction occurred, affording hippadine in 67-74% and pratosine in 62% isolated yield.

SOS1 INHIBITORS

The present invention relates to compounds that inhibit Son of sevenless homolog 1 (SOS1) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

A synthetic camptothecin compound in 5-6 method of and ring structure (by machine translation)

The present invention discloses a synthetic camptothecin compound in the 5 [...] 6 method of and ring structure, the method is that the conjugated structure of formula II occurs in the solvent alkene alkyne ester series cyclization reaction in the molecule, thus the system results in the type shown in I of the 5 [...] 6 and ring structure, the specific equation is: In the formula: R 1 and R 2 are respectively and independently selected from hydrogen, alkyl, cycloalkyl, aryl or heterocyclic group; or, R 1 and R 2 together form a saturated or unsaturated carbocyclic or heterocyclic; R 3 and R 4 are respectively and independently selected from hydrogen, alkyl, cycloalkyl, aryl or heterocyclic group; or, R 3 and R 4 together form a saturated or unsaturated carbocyclic or heterocyclic rings; selected from R C 1-C 4 alkyl; P is amino protecting group. The stated method of this invention has the advantages of simple operation, safety and environmental protection, low production cost, high yield, is suitable for large-scale production, and the like, to promote such compounds in the medical field with the extensive application of an important value. (by machine translation)