3-(Cyclopentylmethyl)pyridine

Base Information

• Chemical Name: 3-(Cyclopentylmethyl)pyridine
• CAS No.: 6311-85-9
• Molecular Formula: C11H15N
• Molecular Weight: 161.2435
• NSC Number: 42639
• DSSTox Substance ID: DTXSID10285689
• Wikidata: Q82021155
• Mol file: 6311-85-9.mol

Synonyms:6311-85-9;3-(cyclopentylmethyl)pyridine;NSC42639;DTXSID10285689;NSC-42639

Chemical Property of 3-(Cyclopentylmethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.0214mmHg at 25°C
• Boiling Point: 259.1°Cat760mmHg
• Flash Point: 131°C
• Density: 1.006g/cm³
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 161.120449483
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)CC2=CN=CC=C2

Technology Process of 3-(Cyclopentylmethyl)pyridine

There total 3 articles about 3-(Cyclopentylmethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) + (cyclopentylmethyl)zinc bromide (226570-69-0) → 3-(cyclopentylmethyl)pyridine (6311-85-9)

Guidance literature:

(cyclopentylmethyl)zinc bromide; With tri-tert-butyl phosphine; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 0.166667h;

3-Bromopyridine; In tetrahydrofuran; for 6h; Heating;

With hydrogenchloride; In tetrahydrofuran; Further stages.;

DOI:10.1002/ejoc.200400349

Reference yield:

3-Methylpyridine (108-99-6) + cyclopentyl chloride (930-28-9) → 3-(cyclopentylmethyl)pyridine (6311-85-9)

Guidance literature:

With ammonia; sodium amide;

DOI:10.1021/ja01650a081

Reference yield:

Cyclopentyl bromide (137-43-9) + 3-Methylpyridine (108-99-6) → 3-(cyclopentylmethyl)pyridine (6311-85-9)

Guidance literature:

With diethyl ether; ammonia; potassium amide;

DOI:10.1021/jo01353a020

upstream raw materials:

Cyclopentyl bromide

3-Methylpyridine

cyclopentyl chloride

3-Bromopyridine

Refernces