4-methyl-N-{5-oxo-7-[4-(propan-2-yl)phenyl]-5,6,7,8-tetrahydroquinazolin-2-yl}benzamide

Base Information

• Chemical Name: 4-methyl-N-{5-oxo-7-[4-(propan-2-yl)phenyl]-5,6,7,8-tetrahydroquinazolin-2-yl}benzamide
• CAS No.: 4901-60-4
• Molecular Formula: C₂₈H₃₄O₈
• Molecular Weight: 498.573
• DSSTox Substance ID: DTXSID90410174

Synonyms:4-methyl-N-{5-oxo-7-[4-(propan-2-yl)phenyl]-5,6,7,8-tetrahydroquinazolin-2-yl}benzamide;4901-60-4;775293-16-8;AC1NPU6X;DTXSID90410174;AKOS002277633;AKOS016308316

Chemical Property of 4-methyl-N-{5-oxo-7-[4-(propan-2-yl)phenyl]-5,6,7,8-tetrahydroquinazolin-2-yl}benzamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.215g/cm³
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 399.19467705
• Heavy Atom Count: 30
• Complexity: 606

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)NC2=NC=C3C(=N2)CC(CC3=O)C4=CC=C(C=C4)C(C)C

Technology Process of 4-methyl-N-{5-oxo-7-[4-(propan-2-yl)phenyl]-5,6,7,8-tetrahydroquinazolin-2-yl}benzamide

There total 2 articles about 4-methyl-N-{5-oxo-7-[4-(propan-2-yl)phenyl]-5,6,7,8-tetrahydroquinazolin-2-yl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl sulfate (77-78-1) + recorcinol (108-46-3) + (2R,3S)-(+)-catechin 3',4',5,7-tetramethyl ether (51079-25-5) → 2-Hydroxy-1-(3,4-dimethoxyphenyl)-1-(2,4-dimethoxyphenyl)-3-(2,4,6-trimethoxyphenyl)-propan (4901-60-4)

Guidance literature:

Multistep reaction; (i) aq. HCl, dioxane, (ii) /BRN= 635994/, aq. KOH, MeOH;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + recorcinol (108-46-3) + 5,7,3',4'-tetra-O-methylepicatechin (51196-02-2) → (+)-2-Hydroxy-1-(3,4-dimethoxyphenyl)-1-(2,4-dimethoxyphenyl)-3-(2,4,6-trimethoxyphenyl)-propan (4901-60-4)

Guidance literature:

Multistep reaction; (i) H⁺, (ii) /BRN= 102415/;

Reference yield:

2-Hydroxy-1-(3,4-dimethoxyphenyl)-1-(2,4-dimethoxyphenyl)-3-(2,4,6-trimethoxyphenyl)-propan (4901-60-4) + methyl iodide (74-88-4) → 2-Methoxy-1-(3,4-dimethoxyphenyl)-1-(2,4-dimethoxyphenyl)-3-(2,4,6-trimethoxyphenyl)-propan

Guidance literature:

With silver(l) oxide;

upstream raw materials:

dimethyl sulfate

recorcinol

(2R,3S)-(+)-catechin 3',4',5,7-tetramethyl ether

diazomethane

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