1-(2-Methoxyphenyl)-1-propanol

Base Information

• Chemical Name: 1-(2-Methoxyphenyl)-1-propanol
• CAS No.: 7452-01-9
• Molecular Formula: C10H14 O2
• Molecular Weight: 166.22
• European Community (EC) Number: 231-221-2
• DSSTox Substance ID: DTXSID10996041
• Nikkaji Number: J278.854C
• Mol file: 7452-01-9.mol

Synonyms:1-(2-Methoxyphenyl)-1-propanol;7452-01-9;1-(2-methoxyphenyl)propan-1-ol;(R)-1-(2-Methoxyphenyl)propanol;(S)-1-(2-Methoxyphenyl)propanol;alpha-Ethyl-o-methoxybenzyl alcohol;1-(2-Methoxyphenyl)propanol;SCHEMBL3929054;DTXSID10996041;EINECS 231-221-2;1-(2-Methoxyphenyl)-1-propanol #;.alpha.-Ethyl-o-methoxybenzyl alcohol;1-(2-Methoxyphenyl)-1-propanol 97;AKOS009536643;Benzenemethanol, alpha-ethyl-2-methoxy-;1-(2-Methoxyphenyl)-1-propanol, 97%;AI3-19308;N14415

Chemical Property of 1-(2-Methoxyphenyl)-1-propanol

Chemical Property:

• Refractive Index: n20/D 1.5290(lit.)
• Boiling Point: 259-260 °C(lit.)
• Flash Point: >230 °F
• PSA: 29.46000
• Density: 1.032 g/mL at 25 °C(lit.)
• LogP: 2.13860
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 166.099379685
• Heavy Atom Count: 12
• Complexity: 125

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Methoxyphenyl)-1-propanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC(C1=CC=CC=C1OC)O
• Uses: 1-(2-Methoxyphenyl)-1-propanol may be used in the preparation of (1-(2-methoxyphenyl)propoxy)trimethylsilane.

Technology Process of 1-(2-Methoxyphenyl)-1-propanol

There total 31 articles about 1-(2-Methoxyphenyl)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Cr(CO)3C6H4(OCH3)CHOHC2H5 → (-)-(S)-1-(o-methoxyphenyl)propanol (7452-01-9,105836-13-3,123879-92-5,114389-71-8)

Guidance literature:

With oxygen; In not given; Irradiation (UV/VIS); O2, sunlight.;

Reference yield: 99.0%

ethylmagnesium bromide (925-90-6) + ortho-anisaldehyde (135-02-4) → 1-(o-methoxyphenyl)-1-propanol (7452-01-9)

Guidance literature:

In diethyl ether; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.8b00612

Reference yield: 99.0%

ortho-anisaldehyde (135-02-4) → 1-(o-methoxyphenyl)-1-propanol (7452-01-9)

Guidance literature:

With titanium(IV) isopropylate; (R,R)-1,1'-bis(1-ferrocenylethanol); In hexane; toluene; at 20 ℃; for 48h;

DOI:10.1016/S0022-328X(02)01139-7

upstream raw materials:

ethylmagnesium bromide

ortho-anisaldehyde

2-(1-propenyl)anisole

ethyllithium

Downstream raw materials:

2-(1-propenyl)anisole

1-(2-methoxyphenyl)-2-(triphenylphosphaneylidene)propan-1-one

C₁₅H₂₀O₃

3-(1'-(2-Methoxyphenyl)propyl)-4-hydroxycoumarin

Refernces

• 1、 Lauzon, Samuel,Ollevier, Thierry. "2,2′-Bipyridine-α,α′-trifluoromethyl-diol ligand: Synthesis and application in the asymmetric Et2Zn alkylation of aldehydes". supporting information. p. 11025 - 11028. Retrieved 2021/11/03.
• 2、 Zhang, Jinxia,Li, Shasha,Zheng, Xinxin,Li, Hongjie,Jiao, Peng. "Chiral zinc amidate catalyzed additions of diethylzinc to aldehydes". supporting information. p. 1913 - 1917. Retrieved 2019/06/24.