N-[4-[[5-[1-(3-chlorophenyl)-4-methoxy-5-[(4-nitrophenyl)diazenyl]pyrazol-3-yl]-1,3,4-oxadiazol-2-yl]methylsulfamoyl]phenyl]acetamide

Base Information

Chemical Name:N-[4-[[5-[1-(3-chlorophenyl)-4-methoxy-5-[(4-nitrophenyl)diazenyl]pyrazol-3-yl]-1,3,4-oxadiazol-2-yl]methylsulfamoyl]phenyl]acetamide
CAS No.:172701-72-3
Molecular Formula:C₂₇H₂₂ClN₉O₇S
Molecular Weight:652.047
Hs Code.:
Mol file:172701-72-3.mol

Synonyms:172701-72-3;N-[4-[[5-[1-(3-chlorophenyl)-4-methoxy-5-[(4-nitrophenyl)diazenyl]pyrazol-3-yl]-1,3,4-oxadiazol-2-yl]methylsulfamoyl]phenyl]acetamide;LS-8660;POOXMVWEDCYGIC-UHFFFAOYSA-N;Acetamide, N-(4-((((5-(1-(3-chlorophenyl)-4-methoxy-5-((4-nitrophenyl)azo)-1H-pyrazol-3-yl)-1,3,4-oxadiazol-2-yl)methyl)amino)sulfonyl)phenyl)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-[[5-[1-(3-chlorophenyl)-4-methoxy-5-[(4-nitrophenyl)diazenyl]pyrazol-3-yl]-1,3,4-oxadiazol-2-yl]methylsulfamoyl]phenyl]acetamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：223.65000
Density:1.58g/cm³
LogP:7.98920
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:10
Exact Mass:651.1051429
Heavy Atom Count:45
Complexity:1140

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NCC2=NN=C(O2)C3=NN(C(=C3OC)N=NC4=CC=C(C=C4)[N+](=O)[O-])C5=CC(=CC=C5)Cl

Technology Process of N-[4-[[5-[1-(3-chlorophenyl)-4-methoxy-5-[(4-nitrophenyl)diazenyl]pyrazol-3-yl]-1,3,4-oxadiazol-2-yl]methylsulfamoyl]phenyl]acetamide

There total 5 articles about N-[4-[[5-[1-(3-chlorophenyl)-4-methoxy-5-[(4-nitrophenyl)diazenyl]pyrazol-3-yl]-1,3,4-oxadiazol-2-yl]methylsulfamoyl]phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: [5-(5-Chloromethyl-[1,3,4]oxadiazol-2-yl)-2-(3-chloro-phenyl)-4-methoxy-2H-pyrazol-3-yl]-(4-nitro-phenyl)-diazene

: 121-61-9
p-acetylaminobenzenesulfonamide

: 172701-72-3
N-[4-({5-[1-(3-Chloro-phenyl)-4-methoxy-5-(4-nitro-phenylazo)-1H-pyrazol-3-yl]-[1,3,4]oxadiazol-2-ylmethyl}-sulfamoyl)-phenyl]-acetamide

Guidance literature:: With potassium carbonate; In methanol; for 10h; Heating;

Reference yield:

: 1-(3-Chloro-phenyl)-4-methoxy-5-(4-nitro-phenylazo)-1H-pyrazole-3-carboxylic acid hydrazide

: 172701-72-3
N-[4-({5-[1-(3-Chloro-phenyl)-4-methoxy-5-(4-nitro-phenylazo)-1H-pyrazol-3-yl]-[1,3,4]oxadiazol-2-ylmethyl}-sulfamoyl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / 7 h / 80 °C

2: 39 percent / POCl₃ / 4 h / 80 °C

3: 82 percent / K₂CO₃ / methanol / 10 h / Heating

With potassium carbonate; trichlorophosphate; In methanol;

Reference yield:

: 1-(3-Chloro-phenyl)-4-hydroxy-5-(4-nitro-phenylazo)-1H-pyrazole-3-carboxylic acid ethyl ester

: 172701-72-3
N-[4-({5-[1-(3-Chloro-phenyl)-4-methoxy-5-(4-nitro-phenylazo)-1H-pyrazol-3-yl]-[1,3,4]oxadiazol-2-ylmethyl}-sulfamoyl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 46 percent / K₂CO₃ / acetone / 12 h / Heating

2: 76 percent / hydrazine hydrate / ethanol / 8 h / Heating

3: 65 percent / 7 h / 80 °C

4: 39 percent / POCl₃ / 4 h / 80 °C

5: 82 percent / K₂CO₃ / methanol / 10 h / Heating

With potassium carbonate; hydrazine hydrate; trichlorophosphate; In methanol; ethanol; acetone;