Technology Process of 5-((3-bromo-2,6-dimethoxybenzamide)methyl)-5-hydroxy-1-ethyl-2-pyrrolidone
There total 13 articles about 5-((3-bromo-2,6-dimethoxybenzamide)methyl)-5-hydroxy-1-ethyl-2-pyrrolidone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: SOCl2, N,N-dimethylformamide / toluene / 1 h / 60 °C
2: 5.3 g / triethylamine / CH2Cl2 / Ambient temperature
3: 1.) lithium diisopropylamide / 1.) THF, hexane, -70 deg C, 1 h, 2.) -60 deg C, 1 h
4: 50 percent / 2 M H2SO4 / H2O / 80 °C
5: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) CH2Cl2, -20 deg C - (-15 deg C), 15 min, 2.) -10 deg C -> 2 deg C, 30 min
6: 100 percent / ammonia / methanol / 0.17 h
With
4-methyl-morpholine; thionyl chloride; sulfuric acid; ammonia; triethylamine; N,N-dimethyl-formamide; lithium diisopropyl amide; isobutyl chloroformate;
In
methanol; dichloromethane; water; toluene;
DOI:10.3891/acta.chem.scand.43-0476
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 5.3 g / triethylamine / CH2Cl2 / Ambient temperature
2: 1.) lithium diisopropylamide / 1.) THF, hexane, -70 deg C, 1 h, 2.) -60 deg C, 1 h
3: 50 percent / 2 M H2SO4 / H2O / 80 °C
4: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) CH2Cl2, -20 deg C - (-15 deg C), 15 min, 2.) -10 deg C -> 2 deg C, 30 min
5: 100 percent / ammonia / methanol / 0.17 h
With
4-methyl-morpholine; sulfuric acid; ammonia; triethylamine; lithium diisopropyl amide; isobutyl chloroformate;
In
methanol; dichloromethane; water;
DOI:10.3891/acta.chem.scand.43-0476
