6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine

Base Information

• Chemical Name: 6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine
• CAS No.: 101724-61-2
• Molecular Formula: C11H11 N5 O2
• Molecular Weight: 245.241
• Mol file: 101724-61-2.mol

Synonyms:Pyrimidine,2,4-diamino-6-(benzyloxy)-5-nitroso- (6CI);2,4-Diamino-6-benzyloxy-5-nitrosopyrimidine; 2,6-Diamino-4-(benzyloxy)-5-nitrosopyrimidine;NU 6039

Chemical Property of 6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine

Chemical Property:

• Vapor Pressure: 1.24E-13mmHg at 25°C
• Melting Point: 204-210 °C (decomp)
• Boiling Point: 584.1°C at 760 mmHg
• PKA: 2.44±0.10(Predicted)
• Flash Point: 307.1°C
• PSA: 117.21000
• Density: 1.49g/cm³
• LogP: 2.12920

Purity/Quality:

99% ^*data from raw suppliers

6-BENZYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine

There total 6 articles about 6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

NU6038 (100061-59-4) → 2,4-diamino-6-(benzyloxy)-5-nitrosopyrimidine (101724-61-2)

Guidance literature:

With acetic acid; sodium nitrite; In water; at 80 ℃; for 1h;

Reference yield:

6-chloro-pyrimidine-2,4-diyldiamine (156-83-2) → 2,4-diamino-6-(benzyloxy)-5-nitrosopyrimidine (101724-61-2)

Guidance literature:

With benzyl alcohol; beim Erwaermen des Reaktionsprodukts mit NaNO₂ und wss. Essigsaeure;

DOI:10.1021/ja01150a130

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 2,4-diamino-6-(benzyloxy)-5-nitrosopyrimidine (101724-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylsulfoxide / 80 °C

2: NaNO₂; aq. AcOH / 80 °C

With sodium hydride; acetic acid; sodium nitrite; In dimethyl sulfoxide;

DOI:10.1016/S0960-894X(02)00884-3

upstream raw materials:

6-chloro-pyrimidine-2,4-diyldiamine

NU₆₀₃₈

benzyl alcohol

Downstream raw materials:

3-(2-amino-6-(benzyloxy)-9H-purin-8-yl)propanoic acid

tert-butyl 2-(3-(2-amino-6-(benzyloxy)-9H-purin-8-yl)propanamido)ethylcarbamate

methyl 3-(2-amino-6-(benzyloxy)-9H-purin-8-yl)propanoate

3,7-anhydro-N-(2-amino-6-benzyloxy-5-nitrosopyrimidin-4-yl)-4,6,8-tri-O-benzyl-5-O-(3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranosuronyl)-2-deoxy-D-glycero-D-talo-octonamide

Refernces

• 1、 Komatsu, Toru,Johnsson, Kai,Okuno, Hiroyuki,Bito, Haruhiko,Inoue, Takanari,Nagano, Tetsuo,Urano, Yasuteru. "Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method". supporting information; scheme or table. p. 6745 - 6751. Retrieved 2011/06/22.
• 2、 George, Tesmol G.,Szolcsanyi, Peter,Koenig, Stefan G.,Paterson, Duncan E.,Isshiki, Yoshiaki,Vasella, Andrea. "Preparation of an advanced intermediate for the synthesis of stable analogues of guanofosfocin". . p. 1287 - 1298. Retrieved 2007/10/03.