(Z)-N-[2-amino-6-(benzyloxy)-5-nitrosopyrimidin-4-yl]-3,7-dimethylocta-2,6-dienamide

Base Information

• Chemical Name: (Z)-N-[2-amino-6-(benzyloxy)-5-nitrosopyrimidin-4-yl]-3,7-dimethylocta-2,6-dienamide
• CAS No.: 939125-17-4
• Molecular Formula: C₂₁H₂₅N₅O₃
• Molecular Weight: 395.461
• Mol file: 939125-17-4.mol

Synonyms:(Z)-N-[2-amino-6-(benzyloxy)-5-nitrosopyrimidin-4-yl]-3,7-dimethylocta-2,6-dienamide

Chemical Property of (Z)-N-[2-amino-6-(benzyloxy)-5-nitrosopyrimidin-4-yl]-3,7-dimethylocta-2,6-dienamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-N-[2-amino-6-(benzyloxy)-5-nitrosopyrimidin-4-yl]-3,7-dimethylocta-2,6-dienamide

There total 2 articles about (Z)-N-[2-amino-6-(benzyloxy)-5-nitrosopyrimidin-4-yl]-3,7-dimethylocta-2,6-dienamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,4-diamino-6-(benzyloxy)-5-nitrosopyrimidine (101724-61-2) + (Z)-geranoyl chloride (56001-53-7) → (Z)-N-[2-amino-6-(benzyloxy)-5-nitrosopyrimidin-4-yl]-3,7-dimethylocta-2,6-dienamide (939125-17-4)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at -18 ℃; for 2.5h;

DOI:10.1002/hlca.200790054

Reference yield:

nerolic acid (4613-38-1) → (Z)-N-[2-amino-6-(benzyloxy)-5-nitrosopyrimidin-4-yl]-3,7-dimethylocta-2,6-dienamide (939125-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. NaOH / 0.17 h / 20 °C

1.2: 80 percent / oxalyl chloride; pyridine / toluene / 0.83 h

2.1: 80 percent / K₂CO₃ / tetrahydrofuran / 2.5 h / -18 °C

With sodium hydroxide; potassium carbonate; In tetrahydrofuran;

DOI:10.1002/hlca.200790054

Reference yield: 98.0%

(Z)-N-[2-amino-6-(benzyloxy)-5-nitrosopyrimidin-4-yl]-3,7-dimethylocta-2,6-dienamide (939125-17-4) → 2-amino-4-(benzyloxy)-6-[5-methyl-1-methylidenehex-4-enyl]pteridin-7(8H)-one

Guidance literature:

In dichloromethane; at 23 ℃; for 96h;

DOI:10.1002/hlca.200790054

upstream raw materials:

2,4-diamino-6-(benzyloxy)-5-nitrosopyrimidine

(Z)-geranoyl chloride

nerolic acid