1-methylpiperidine-3,3-diol hydrobromide (1:1)

Base Information

• Chemical Name: 1-methylpiperidine-3,3-diol hydrobromide (1:1)
• CAS No.: 114506-99-9
• Molecular Formula: C6H13 N O2 . Br H
• Molecular Weight: 212.087
• Mol file: 114506-99-9.mol

Synonyms:3,3-Piperidinediol,1-methyl-, hydrobromide (9CI)

Chemical Property of 1-methylpiperidine-3,3-diol hydrobromide (1:1)

Chemical Property:

• Vapor Pressure: 0.0158mmHg at 25°C
• Boiling Point: 226.8°Cat760mmHg
• Flash Point: 113.5°C
• Density: g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methylpiperidine-3,3-diol hydrobromide (1:1)

There total 1 articles about 1-methylpiperidine-3,3-diol hydrobromide (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine (98435-42-8) → N-methyl-3-piperidinone hydrobromide hydrate (114506-99-9)

Guidance literature:

With hydrogen bromide; for 5h; Heating;

DOI:10.1021/jm00403a013

Reference yield:

N-methyl-3-piperidinone hydrobromide hydrate (114506-99-9) → 1-methyl-3-piperidone (5519-50-6)

Guidance literature:

With potassium carbonate;

DOI:10.1021/jm00403a013

Reference yield:

N-methyl-3-piperidinone hydrobromide hydrate (114506-99-9) → (Z)-N-methyl-3-(phenylmethylene)piperidine (114507-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. K₂CO₃

2: 1.10 g / NaH / 1,2-dimethoxy-ethane / 1.5 h / Heating

With sodium hydride; potassium carbonate; In 1,2-dimethoxyethane;

DOI:10.1021/jm00403a013

upstream raw materials:

3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine

Downstream raw materials:

1-methyl-3-piperidone

(Z)-N-methyl-3-(phenylmethylene)piperidine

(E)-N-methyl-3-(phenylmethylene)piperidine

(Z)-N-methyl-3-(phenylmethylene)piperidine hydrochloride

Refernces