3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine

Base Information

• Chemical Name: 3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine
• CAS No.: 98435-42-8
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.186
• Hs Code.: 2933399990
• Mol file: 98435-42-8.mol

Synonyms:3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine

Chemical Property of 3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-methoxy-1-methyl-1,2,3,6-tetrahydropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine

There total 2 articles about 3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-HYDROXYPYRIDINE (109-00-2) + methyl iodide (74-88-4) → 3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine (98435-42-8)

Guidance literature:

With sodium tetrahydroborate; sodium methylate; Yield given. Multistep reaction; 1.) methanol, reflux, 2.) 0 deg C, 1 h, room temperature, 2 h;

DOI:10.1021/jm00403a013

Reference yield:

3-HYDROXYPYRIDINE (109-00-2) + sodium methylate (124-41-4) + methyl iodide (74-88-4) → 3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine (98435-42-8)

Guidance literature:

With methanol; und anschliessenden Behandeln der Reaktionsloesung mit Natriumboranat;

DOI:10.1021/jo01085a012

Reference yield: 100.0%

3-methoxy-1-methyl-1,2,5,6-tetrahydropyridine (98435-42-8) + toluene-4-sulfonic acid (104-15-4) → 3-methoxy-1-methyl-1,2,5,6-tetrahydropyridinium toluene-p-sulphonate (135625-83-1)

Guidance literature:

In acetone; for 0.25h; educt toluene-p-sulphonic acid: anhydrous;

upstream raw materials:

3-HYDROXYPYRIDINE

sodium methylate

methyl iodide

Downstream raw materials:

1-methyl-3-piperidone

1-methyl-3-oxopiperidinium toluene-p-sulphonate

3-methoxy-1-methyl-1,2,5,6-tetrahydropyridinium toluene-p-sulphonate

N-methyl-3-piperidinone hydrobromide hydrate

Refernces