1-BROMO-2-FLUORO-2-METHYLPROPANE

Base Information

• Chemical Name: 1-BROMO-2-FLUORO-2-METHYLPROPANE
• CAS No.: 19869-78-4
• Molecular Formula: C4H8 Br F
• Molecular Weight: 155.01
• Hs Code.: 2903799090
• Mol file: 19869-78-4.mol

Synonyms:1-Bromo-2-fluoro-2-methylpropane

Chemical Property of 1-BROMO-2-FLUORO-2-METHYLPROPANE

Chemical Property:

• Vapor Pressure: 42.3mmHg at 25°C
• Boiling Point: 100.4°Cat760mmHg
• Flash Point: 15.9°C
• PSA: 0.00000
• Density: 1.368g/cm³
• LogP: 2.12940

Purity/Quality:

97% ^*data from raw suppliers

1-Bromo-2-fluoro-2-methylpropane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-BROMO-2-FLUORO-2-METHYLPROPANE is a bromofluoroalkyl compound used in the preparation for fluoromethyl amino acids.

Technology Process of 1-BROMO-2-FLUORO-2-METHYLPROPANE

There total 2 articles about 1-BROMO-2-FLUORO-2-METHYLPROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2-fluoro-2-methylpropyl) trifluoromethanesulfonate (145349-17-3) → 1-bromo-2-fluoro-2-methylpropane (19869-78-4)

Guidance literature:

With sodium bromide; In N,N-dimethyl-formamide;

DOI:10.1021/jo047918j

Reference yield: 53.0%

isobutene (115-11-7,15220-85-6) → 1-bromo-2-fluoro-2-methylpropane (19869-78-4)

Guidance literature:

With N-Bromosuccinimide; triethylamine tris(hydrogen fluoride); In dichloromethane; at 0 - 20 ℃; for 15.25h; regioselective reaction;

DOI:10.15227/orgsyn.076.0159

Reference yield: 84.0%

1-bromo-2-fluoro-2-methylpropane (19869-78-4) + (4-(3-fluoro-4-(piperidin-4-ylmethoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone hydrochloride → (4-(3-fluoro-4-((1-(2-fluoro-2-methylpropyl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone

Guidance literature:

With triethylamine; In tetrahydrofuran; at 40 ℃; for 3h; Inert atmosphere;

upstream raw materials:

isobutene

(2-fluoro-2-methylpropyl) trifluoromethanesulfonate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 19869-78-4 1-BROMO-2-FLUORO-2-METHYLPROPANE

Send

Send

Metric Ton KG G Pound L ML

Send

Send