3,4-dichloro-N-methyl-N-(3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-7-yl)benzeneacetamide

Base Information

Chemical Name:3,4-dichloro-N-methyl-N-(3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-7-yl)benzeneacetamide
CAS No.:141269-53-6
Molecular Formula:C₂₃H₂₈Cl₂N₂O₃
Molecular Weight:451.393
Hs Code.:
Mol file:141269-53-6.mol

Synonyms:Benzeneacetamide,3,4-dichloro-N-methyl-N-[3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-7-yl]-,(5a,7a,8b)- (9CI); Benzeneacetamide,3,4-dichloro-N-methyl-N-[3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-7-yl]-,(5a,7a,8b)-(?à)-; 1-Oxaspiro[4.5]decane,benzeneacetamide deriv.

Suppliers and Price of 3,4-dichloro-N-methyl-N-(3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-7-yl)benzeneacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 3,4-dichloro-N-methyl-N-(3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-7-yl)benzeneacetamide

Chemical Property:

Vapor Pressure:8.63E-16mmHg at 25°C
Boiling Point:630.2°Cat760mmHg
Flash Point:334.9°C
PSA：49.85000
Density:1.31g/cm³
LogP:4.19100

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3,4-dichloro-N-methyl-N-(3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-7-yl)benzeneacetamide

There total 18 articles about 3,4-dichloro-N-methyl-N-(3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-7-yl)benzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: (+/-)-trans-3,4-dichloro-N-methyl-N-<2-(1-pyrrolidinyl)-5-oxocyclohexyl>benzeneacetamide

: 17435-72-2
ethyl 2-bromomethyl-2-propenoate

: 141269-53-6
(+/-)-(5β,7α,8β)-3,4-dichloro-N-methyl-N-<3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro<4,5>dec-7-yl>benzeneacetamide

: 141269-53-6
(+/-)-(5α,7α,8β)-3,4-dichloro-N-methyl-N-<3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro<4,5>dec-7-yl>benzeneacetamide

Guidance literature:: With zinc; In tetrahydrofuran; at 40 - 45 ℃; for 3h;
DOI:10.1021/jm00090a015

Reference yield: 21.0%

: (+/-)-trans-3,4-dichloro-N-methyl-N-<2-(1-pyrrolidinyl)-5-oxocyclohexyl>benzeneacetamide

: 17435-72-2
ethyl 2-bromomethyl-2-propenoate

: 141269-53-6
(+/-)-(5β,7α,8β)-3,4-dichloro-N-methyl-N-<3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro<4,5>dec-7-yl>benzeneacetamide

: 141269-53-6
(+/-)-(5α,7α,8β)-3,4-dichloro-N-methyl-N-<3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro<4,5>dec-7-yl>benzeneacetamide

Guidance literature:: With zinc; In tetrahydrofuran; at 40 - 45 ℃; for 3h;
DOI:10.1021/jm00090a015

Reference yield:

: 22428-87-1
4,4-ethylenedioxycyclohexan-1-ol

: 141269-53-6
(+/-)-(5β,7α,8β)-3,4-dichloro-N-methyl-N-<3-methylene-2-oxo-8-(1-pyrrolidinyl)-1-oxaspiro<4,5>dec-7-yl>benzeneacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 2.5 h / 0 °C

2: 21.4 g / DBU / 26 h / 100 - 110 °C

3: m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / 0 °C

5: 77.5 percent / 2N H₂SO₄ / methanol / 24 h / Heating

6: 56 percent / Zn / tetrahydrofuran / 3 h / 40 - 45 °C

With sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00090a015