1,4-DIOXA-SPIRO[4.5]DECAN-8-OL

Base Information

• Chemical Name: 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL
• CAS No.: 22428-87-1
• Molecular Formula: C8H14O3
• Molecular Weight: 158.197
• Hs Code.: 29339900
• Mol file: 22428-87-1.mol

Synonyms:1,4-Dioxaspiro[4.5]decane-8-ol;1-Hydroxy-4-cyclohexanone ethylene ketal;4,4-Ethylenedioxycyclohexanol;4-(Ethylenedioxy)cyclohexanol;4-Hydroxycyclohexanone cyclic ethylene ketal;8-Hydroxy-1,4-dioxaspiro[4.5]decane;

Chemical Property of 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL

Chemical Property:

• Appearance/Colour: clear colorless viscous liquid
• Vapor Pressure: 0.000993mmHg at 25°C
• Refractive Index: 1.485-1.487
• Boiling Point: 269.012 °C at 760 mmHg
• PKA: 15.11±0.20(Predicted)
• Flash Point: 116.495 °C
• PSA: 38.69000
• Density: 1.174 g/cm³
• LogP: 0.66440
• Storage Temp.: Refrigerator (+4°C)

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,4-Dioxaspiro[4.5]decan-8-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,4-Dioxaspiro[4.5]decan-8-ol can be used to synthesize pharmaceutical compounds such as diuretics.

Technology Process of 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL

There total 1 articles about 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dioxaspiro[4.5]decan-6-one (4746-96-7) + water (7732-18-5) → 4,4-ethylenedioxycyclohexan-1-ol (22428-87-1)

Guidance literature:

With sodium borohydrid; In diethyl ether; ethanol;

Reference yield: 100.0%

4,4-ethylenedioxycyclohexan-1-ol (22428-87-1) + benzyl bromide (100-39-0) → 1,4-dioxaspiro<4,5>decan-8-ol benzyl ether (92829-83-9)

Guidance literature:

4,4-ethylenedioxycyclohexan-1-ol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1.5h;

benzyl bromide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 99.0%

4,4-ethylenedioxycyclohexan-1-ol (22428-87-1) → 4-hydroxycyclohexanone (13482-22-9)

Guidance literature:

With water; toluene-4-sulfonic acid; for 2h; Heating;

upstream raw materials:

1,4-dioxaspiro[4.5]decan-6-one

water

Downstream raw materials:

cyclohexanedione monoethylene ketal

8-(dimethylamino)-1,4-dioxaspiro-[4.5]-decane-8-carbonitrile

1,4-dioxaspiro<4,5>decan-8-ol benzyl ether

8-methylsulfonyloxy-1,4-dioxaspiro[4.5]decane

Refernces