4-(3-hydroxyestra-1,3,5(10)-tetraen-16-yl)-2-methylene-4-butanolide

Base Information

Chemical Name:4-(3-hydroxyestra-1,3,5(10)-tetraen-16-yl)-2-methylene-4-butanolide
CAS No.:150585-14-1
Molecular Formula:C₂₃H₂₆O₃
Molecular Weight:350.458
Hs Code.:
Mol file:150585-14-1.mol

Synonyms:4-(3-hydroxyestra-1,3,5(10)-tetraen-16-yl)-2-methylene-4-butanolide

Suppliers and Price of 4-(3-hydroxyestra-1,3,5(10)-tetraen-16-yl)-2-methylene-4-butanolide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-(3-hydroxyestra-1,3,5(10)-tetraen-16-yl)-2-methylene-4-butanolide

Chemical Property:

PSA：46.53000
LogP:4.65630

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4-(3-hydroxyestra-1,3,5(10)-tetraen-16-yl)-2-methylene-4-butanolide

There total 5 articles about 4-(3-hydroxyestra-1,3,5(10)-tetraen-16-yl)-2-methylene-4-butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 150585-07-2
16-formylestra-1,3,5⁽¹⁰⁾,16-tetraen-3-ol

: 17435-72-2
ethyl 2-bromomethyl-2-propenoate

: 150585-14-1
4-(3-hydroxyestra-1,3,5(10),16-tetraen-16-yl)-2-methylene-4-butanolide

Guidance literature:: With hydroquinone; zinc; In tetrahydrofuran; Heating;
DOI:10.1016/0039-128X(93)90025-I

Reference yield:

: 53-16-7
Estrone

: 150585-14-1
4-(3-hydroxyestra-1,3,5(10),16-tetraen-16-yl)-2-methylene-4-butanolide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sodium hydride / 1.) benzene, 1 h, 2.) benzene, RT

2: 81 percent / MgSO₄, p-toluenesulfonic acid (p-TSA) / 1,2-dimethoxy-ethane / 60 °C

3: 80 percent / sodium borohydride / methanol / 2 h

4: 52 percent / TiCl₄ / acetonitrile; H₂O / 4.33 h

5: 40 percent / zinc, p-dihydroquinone / tetrahydrofuran / Heating

With sodium tetrahydroborate; titanium tetrachloride; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; hydroquinone; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetonitrile;
DOI:10.1016/0039-128X(93)90025-I

Reference yield:

: 3460-92-2
3-hydroxy-16-hydroxymethylideneestra-1,3,5⁽¹⁰⁾-trien-17-one

: 150585-14-1
4-(3-hydroxyestra-1,3,5(10),16-tetraen-16-yl)-2-methylene-4-butanolide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / MgSO₄, p-toluenesulfonic acid (p-TSA) / 1,2-dimethoxy-ethane / 60 °C

2: 80 percent / sodium borohydride / methanol / 2 h

3: 52 percent / TiCl₄ / acetonitrile; H₂O / 4.33 h

4: 40 percent / zinc, p-dihydroquinone / tetrahydrofuran / Heating

With sodium tetrahydroborate; titanium tetrachloride; magnesium sulfate; toluene-4-sulfonic acid; hydroquinone; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetonitrile;
DOI:10.1016/0039-128X(93)90025-I