21-deoxytetrahydroaldosterone

Base Information

Chemical Name:21-deoxytetrahydroaldosterone
CAS No.:6251-70-3
Molecular Formula:C₂₁H₃₂O₄
Molecular Weight:348.483
Hs Code.:

Synonyms:5b-Pregnan-18-al, 3a,11b-dihydroxy-20-oxo-, cyclic 18,11-hemiacetal (7CI);11,13-(Epoxymethano)-13H-cyclopenta[a]phenanthrene, pregnan-20-one deriv.;21-Deoxytetrahydroaldosterone

Suppliers and Price of 21-deoxytetrahydroaldosterone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 21-deoxytetrahydroaldosterone

Chemical Property:

Vapor Pressure:9.24E-13mmHg at 25°C
Boiling Point:515°C at 760 mmHg
Flash Point:179.3°C
PSA：66.76000
Density:1.23g/cm³
LogP:2.90240

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 21-deoxytetrahydroaldosterone

There total 11 articles about 21-deoxytetrahydroaldosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610-52-2
3α-acetoxy-5β-pregnane-11,20-dione

: 6251-70-3
11β,18-epoxy-3α,18-dihydroxy-5β-pregnan-20-one

Guidance literature:: Multi-step reaction with 10 steps

1: NaBH₄ / methanol; H₂O / 1.5 h / 0 °C

2: 1.) lead tetra-acetate, iodine, 2.) Jones' chromic acid reagent / .) cyclohexane, reflux, irradiated, 1.5 h, 2.) acetone, 0 deg C, 1 h

3: potassium carbonate / methanol; H₂O / 1 h / Heating

4: toluene-p-sulphonic acid monohydrate / tetrahydrofuran / 1.5 h / Ambient temperature

5: 7 percent / zinc borohydride / 1,2-dimethoxy-ethane / 1.5 h / Heating

6: 73 percent / pyridine / 24 h / Ambient temperature

7: 1.) chloroform, 2.) 2,3-dihydropyran, toluene-p-sulphonic acid / 1.) room temperature, 30 min, 2.) THF, room temperature, 6 h

8: 72 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

9: 83 percent / CrO₃, pyridine / CH₂Cl₂ / 24 h / Ambient temperature

10: 1.0 M HCl / tetrahydrofuran / 24 h / Ambient temperature

With pyridine; 3,4-dihydro-2H-pyran; chromium(VI) oxide; lead(IV) acetate; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; chloroform; zinc borohydride; iodine; chromic acid; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1053-19-6
3α-acetoxy-20β-hydroxy-5β-pregnan-11-one

: 6251-70-3
11β,18-epoxy-3α,18-dihydroxy-5β-pregnan-20-one

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) lead tetra-acetate, iodine, 2.) Jones' chromic acid reagent / .) cyclohexane, reflux, irradiated, 1.5 h, 2.) acetone, 0 deg C, 1 h

2: potassium carbonate / methanol; H₂O / 1 h / Heating

3: toluene-p-sulphonic acid monohydrate / tetrahydrofuran / 1.5 h / Ambient temperature

4: 7 percent / zinc borohydride / 1,2-dimethoxy-ethane / 1.5 h / Heating

5: 73 percent / pyridine / 24 h / Ambient temperature

6: 1.) chloroform, 2.) 2,3-dihydropyran, toluene-p-sulphonic acid / 1.) room temperature, 30 min, 2.) THF, room temperature, 6 h

7: 72 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

8: 83 percent / CrO₃, pyridine / CH₂Cl₂ / 24 h / Ambient temperature

9: 1.0 M HCl / tetrahydrofuran / 24 h / Ambient temperature

With pyridine; 3,4-dihydro-2H-pyran; chromium(VI) oxide; lead(IV) acetate; hydrogenchloride; lithium aluminium tetrahydride; chloroform; zinc borohydride; iodine; chromic acid; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 76183-73-8
3α-hydroxy-11-oxo-5β-pregnano-18,20β-lactone

: 6251-70-3
11β,18-epoxy-3α,18-dihydroxy-5β-pregnan-20-one

Guidance literature:: Multi-step reaction with 7 steps

1: toluene-p-sulphonic acid monohydrate / tetrahydrofuran / 1.5 h / Ambient temperature

2: 7 percent / zinc borohydride / 1,2-dimethoxy-ethane / 1.5 h / Heating

3: 73 percent / pyridine / 24 h / Ambient temperature

4: 1.) chloroform, 2.) 2,3-dihydropyran, toluene-p-sulphonic acid / 1.) room temperature, 30 min, 2.) THF, room temperature, 6 h

5: 72 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

6: 83 percent / CrO₃, pyridine / CH₂Cl₂ / 24 h / Ambient temperature

7: 1.0 M HCl / tetrahydrofuran / 24 h / Ambient temperature

With pyridine; 3,4-dihydro-2H-pyran; chromium(VI) oxide; hydrogenchloride; lithium aluminium tetrahydride; chloroform; zinc borohydride; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; 1,2-dimethoxyethane; dichloromethane;