1610-52-2Relevant articles and documents
A Very Short Degradation of the Bile Acid Side Chain
Barton, Derek H. R.,Wozniak, Jocelyne,Sard, Samir Z.
, p. 1383 - 1385 (1987)
Reaction of the cholanic acid derivative (1) with thionyl chloride and pyridine gave, after quenching with methanol, the α-sulphine ester (3); treatment with acetic anhydride-sulphuric acid afforded the keto ester (5) which, on exposure to air in the presence of copper(II) ions and base, gave the 20-keto pregnane derivative (9) in excellent overall yield.
Novel 23-keto-steroids
-
, (2008/06/13)
A compound of the formula STR1 wherein R1 is hydrogen or methyl, R2 is methyl or ethyl, and A,B,C and D rings optionally containing at least one double bond and optionally substituted with at least one member of the group consisting of optionally protected --OH, =O, alkyl and alkoxy of 1 to 4 carbon atoms, halogen and alkenyl and alkynyl of 2 to 4 carbon atoms, R is selected from the group consisting of halogen, --OH, alkylthio and alkoxy of 1 to 6 carbon atoms, aralkoxy, arylthio and aralkylthio of 7 to 15 carbon atoms and STR2 R3 and R4 are individually hydrogen, or alkyl of 1 to 6 carbon atoms or aralkyl of 7 to 15 carbon atoms or taken together with the nitrogen form a heterocycle optionally containing another nitrogen or oxygen atom, excepting the product in which R is methoxy, R1 and R2 each represent methyl, A ring carries a 3β-acetoxy function and B ring contains a double bond in 5(6) useful as intermediates for the preparation of 20-keto-pregnanes.
Novel steroids
-
, (2008/06/13)
A compound of the formula STR1 wherein R1 is hydrogen or methyl, R2 is methyl or ethyl, the A,B,C and D rings optionally have one or more double bonds and are optionally substituted with one or more members of the group consisting of halogen protected hydroxy, 1/8O, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R is selected from the group consisting of halogen, --OH, alkoxy of 1 to 6 carbon atoms, aralkoxy of 7 to 15 carbon atoms, alkylthio of 1 to 6 carbon atoms, arylthio of 6 to 14 carbon atoms, aralkylthio of 7 to 15 carbon atoms and STR2 wherein R3 and R4 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and aralkyl of 7 to 15 carbon atoms or R3 and R4 together with the nitrogen atom form another heterocycle optionally containing a nitrogen atom or oxygen atom and their preparation and their use to form 20-keto-pregnanes.
