2-(1-Benzylpiperidin-4-yl)-2-phenylacetonitrile

Base Information

Chemical Name:2-(1-Benzylpiperidin-4-yl)-2-phenylacetonitrile
CAS No.:7254-21-9
Molecular Formula:C20H22N2
Molecular Weight:290.408
Hs Code.:
European Community (EC) Number:230-674-3
NSC Number:73399
DSSTox Substance ID:DTXSID901226557
Nikkaji Number:J212.268E
ChEMBL ID:CHEMBL1621827
Mol file:7254-21-9.mol

Synonyms:7254-21-9;2-(1-benzylpiperidin-4-yl)-2-phenylacetonitrile;1-Benzyl-alpha-phenylpiperidine-4-acetonitrile;1-benzyl-4-(alpha-cyanobenzyl)-piperidine;EINECS 230-674-3;NSC73399;SCHEMBL4528662;CHEMBL1621827;DTXSID901226557;NSC 73399;NSC-73399;AKOS024323085;NCGC00247085-01;CS-0257690;FT-0607400;EN300-6757625;alpha-Phenyl-1-phenylmethyl-4-piperidineacetonitrile;alpha-phenyl-1-(phenylmethyl)-4-piperidineacetonitrile;Z2050059108

Suppliers and Price of 2-(1-Benzylpiperidin-4-yl)-2-phenylacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 2-(1-Benzylpiperidin-4-yl)-2-phenylacetonitrile

Chemical Property:

Vapor Pressure:1.45E-07mmHg at 25°C
Boiling Point:429°Cat760mmHg
Flash Point:180.3°C
PSA：27.03000
Density:1.096g/cm³
LogP:4.14388
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:290.178298710
Heavy Atom Count:22
Complexity:362

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1C(C#N)C2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of 2-(1-Benzylpiperidin-4-yl)-2-phenylacetonitrile

There total 5 articles about 2-(1-Benzylpiperidin-4-yl)-2-phenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 6517-69-7
<1-benzylpiperidylidine-(4)>-phenylacetonitrile

: 7254-21-9
N-benzyl-2-phenyl-2-(piperidin-4-yl)acetonitrile

Guidance literature:: With methanol; sodium tetrahydroborate; at 20 ℃;

Reference yield: 61.0%

: 3612-20-2
1-phenylmethyl-4-piperidone

: 140-29-4
phenylacetonitrile

: 7254-21-9
N-benzyl-2-phenyl-2-(piperidin-4-yl)acetonitrile

Guidance literature:: 1-phenylmethyl-4-piperidone; phenylacetonitrile; With sodium methylate; In methanol; Inert atmosphere; Reflux;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1002/anie.201711828

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 7254-21-9
N-benzyl-2-phenyl-2-(piperidin-4-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / Inert atmosphere; Reflux

2: sodium tetrahydroborate; methanol / 20 °C

With methanol; sodium tetrahydroborate; sodium methylate; In methanol;