rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentyl methylcarbamate

Base Information

Chemical Name:rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentyl methylcarbamate
CAS No.:2363165-42-6
Molecular Formula:C₃₇H₄₇N₅O₄S
Molecular Weight:657.877
Hs Code.:

rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentyl methylcarbamate

Synonyms:

Suppliers and Price of rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentyl methylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentyl methylcarbamate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentyl methylcarbamate

There total 14 articles about rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentyl methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentan-1-ol

: 624-83-9
methyl isocyanate

: 2363165-42-6
rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentyl methylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 7254-21-9
N-benzyl-2-phenyl-2-(piperidin-4-yl)acetonitrile

: 2363165-42-6
rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentyl methylcarbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium hydride / tetrahydrofuran; toluene; mineral oil / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: diisobutylaluminium hydride / toluene / 20 °C

4.1: sodium tetrahydroborate; methanol

5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6.1: acetic acid; trifluoroacetic acid / 20 °C

7.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.5 h / 20 °C

8.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 760.05 Torr

9.1: potassium carbonate; potassium iodide / acetonitrile / 80 °C

10.1: triethylamine / dichloromethane / 4 h / 20 °C

With methanol; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; mineral oil;

Reference yield:

: rac-2-(1-benzylpiperidin-4-yl)-2-((1R,2S)-2-hydroxycyclopentyl)-2-phenylacetonitrile

: 2363165-42-6
rac-(1S,2R)-2-(2-methyl-4-(1-((1-(4-(pyridin-4-ylsulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)-1,2,3,4-tetrahydroisoquinolin-4-yl)cyclopentyl methylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran; toluene; mineral oil / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: diisobutylaluminium hydride / toluene / 20 °C

3.1: sodium tetrahydroborate; methanol

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5.1: acetic acid; trifluoroacetic acid / 20 °C

6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.5 h / 20 °C

7.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 760.05 Torr

8.1: potassium carbonate; potassium iodide / acetonitrile / 80 °C

9.1: triethylamine / dichloromethane / 4 h / 20 °C

With methanol; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; mineral oil;