(2S)-{[(2R,3R)-2-amino-3-hydroxy-4-(4-hydroxyphenyl)butanoyl]amino}[(3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]ethanoic acid (non-preferred name)

Base Information

Chemical Name:(2S)-{[(2R,3R)-2-amino-3-hydroxy-4-(4-hydroxyphenyl)butanoyl]amino}[(3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]ethanoic acid (non-preferred name)
CAS No.:93806-77-0
Molecular Formula:C20H24N4O10
Molecular Weight:480.4254
Hs Code.:

(2S)-{[(2R,3R)-2-amino-3-hydroxy-4-(4-hydroxyphenyl)butanoyl]amino}[(3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]ethanoic acid (non-preferred name)

Synonyms:

Suppliers and Price of (2S)-{[(2R,3R)-2-amino-3-hydroxy-4-(4-hydroxyphenyl)butanoyl]amino}[(3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]ethanoic acid (non-preferred name)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-{[(2R,3R)-2-amino-3-hydroxy-4-(4-hydroxyphenyl)butanoyl]amino}[(3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]ethanoic acid (non-preferred name)

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.653g/cm³

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S)-{[(2R,3R)-2-amino-3-hydroxy-4-(4-hydroxyphenyl)butanoyl]amino}[(3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]ethanoic acid (non-preferred name)

There total 4 articles about (2S)-{[(2R,3R)-2-amino-3-hydroxy-4-(4-hydroxyphenyl)butanoyl]amino}[(3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]ethanoic acid (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93806-78-1
(S)-[(2S,3R)-2-Benzyloxycarbonylamino-4-(4-benzyloxycarbonyloxy-phenyl)-3-hydroxy-butyrylamino]-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid

: 93806-77-0
1-<5'-<<(2S,3R)-3-hydroxyhomotyrosyl>amino>-5'-deoxy-β-D-allofuranosyluronic acid>uracil

Guidance literature:: With hydrogen; acetic acid; Pd-BaSO₄; In methanol; water; for 1h; Yield given;
DOI:10.1021/jm00381a012

Reference yield:

: 74281-82-6
(2S,3R)-3-hydroxyhomotyrosine

: 93806-77-0
1-<5'-<<(2S,3R)-3-hydroxyhomotyrosyl>amino>-5'-deoxy-β-D-allofuranosyluronic acid>uracil

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH

2: DCC / ethyl acetate; dimethylformamide

3: Et₃N / dimethylformamide; H₂O / 48 h / Ambient temperature

4: AcOH, H₂ / Pd/BaSO₄ / methanol; H₂O / 1 h

With sodium hydroxide; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; Pd-BaSO₄; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00381a012

Reference yield:

: (2S,3R)-N-carbobenzoxy-4'-O-carbobenzoxy-3-hydroxyhomotyrosine

: 93806-77-0
1-<5'-<<(2S,3R)-3-hydroxyhomotyrosyl>amino>-5'-deoxy-β-D-allofuranosyluronic acid>uracil

Guidance literature:: Multi-step reaction with 3 steps

1: DCC / ethyl acetate; dimethylformamide

2: Et₃N / dimethylformamide; H₂O / 48 h / Ambient temperature

3: AcOH, H₂ / Pd/BaSO₄ / methanol; H₂O / 1 h

With hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; Pd-BaSO₄; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00381a012