ethyl 2-hydroxy-3,3-diphenylpropanoate

Base Information

• Chemical Name: ethyl 2-hydroxy-3,3-diphenylpropanoate
• CAS No.: 5449-42-3
• Molecular Formula: C17H18O3
• Molecular Weight: 270.328
• Hs Code.: 2918199090
• Mol file: 5449-42-3.mol

Synonyms:2-Hydroxy-3,3-diphenyl-propionsaeure-aethylester;2-hydroxy-3,3-diphenyl-propionic acid ethyl ester;

Chemical Property of ethyl 2-hydroxy-3,3-diphenylpropanoate

Chemical Property:

• Vapor Pressure: 3.24E-07mmHg at 25°C
• Boiling Point: 402.9°Cat760mmHg
• Flash Point: 164.9°C
• PSA: 46.53000
• Density: 1.14g/cm³
• LogP: 2.74250

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-hydroxy-3,3-diphenylpropanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-hydroxy-3,3-diphenylpropanoate

There total 8 articles about ethyl 2-hydroxy-3,3-diphenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3,3-diphenyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-propionic acid ethyl ester → ethyl 2-hydroxy-3,3-diphenylpropanoate (5449-42-3)

Guidance literature:

With zinc; In tetrahydrofuran; water; acetic acid; at 50 ℃;

DOI:10.1021/jo981180m

Reference yield: 76.0%

potassium phenyltrifluoborate + ethyl trans-3-phenyl-1-oxirane-2-carboxylate (2272-55-1) → ethyl 2-hydroxy-3,3-diphenylpropanoate (5449-42-3)

Guidance literature:

With trifluoroacetic anhydride; In dichloromethane; at 20 ℃; for 3h; regioselective reaction;

DOI:10.1039/c3cc47360k

Reference yield:

→ ethyl 2-hydroxy-3,3-diphenylpropanoate (5449-42-3)

Guidance literature:

With nickel; Hydrogenation;

DOI:10.1021/ja01641a013

upstream raw materials:

diphenyl-α-oxo-propionic acid

3,3-diphenyl-propionic acid ethyl ester

benzophenone

ethyl 2-oxo-3,3-diphenylpropanoate

Refernces

• 1、 Jahn, Ullrich. "Highly efficient generation of radicals from ester enolates by the ferrocenium ion. application to selective α-oxygenation and dimerization reactions of esters". . p. 7130 - 7131. Retrieved 2007/10/03.