11-oxahomoaminopterin

Base Information

Chemical Name:11-oxahomoaminopterin
CAS No.:78520-72-6
Molecular Formula:C20H21 N7 O6
Molecular Weight:455.42404
Hs Code.:2933990090
Mol file:78520-72-6.mol

Synonyms:NSC 325304

Suppliers and Price of 11-oxahomoaminopterin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 11-oxahomoaminopterin

Chemical Property:

PSA：216.53000
Density:1.527g/cm³
LogP:1.80680

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 11-oxahomoaminopterin

There total 12 articles about 11-oxahomoaminopterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 78520-72-6
4-amino-4-deoxy-11-oxahomoaminopterin

Guidance literature:: Multi-step reaction with 8 steps

1: N-methylmorpholine, isobutyl chloroformate / 1.) DMF, 20 min, 2.) DMF, RT, 18 h

2: H₂ / 5percent Pd/C / methanol / 18 h / 1292.9 Torr

3: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, 2 h

4: 94.8 percent / 1N HCl, trifluoroacetic acid / 55 °C

5: sodium dithionite / dimethylformamide; H₂O / 0.5 h

6: 0.1N NaOH / 1.5 h

7: Me₂SO / dimethylformamide / 47 h

8: 0.1N NaOH / acetonitrile

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium dithionite; hydrogen; dimethyl sulfoxide; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00141a010

Reference yield:

: 78520-73-7
1-azido-4--2-butanone

: 78520-72-6
4-amino-4-deoxy-11-oxahomoaminopterin

Guidance literature:: Multi-step reaction with 10 steps

1: 82 percent / p-toluenesulfonic acid monohydrate / benzene / 6 h / Heating

2: 93.5 percent / 0.5 N NaOH / acetonitrile / 18 h / Ambient temperature

3: N-methylmorpholine, isobutyl chloroformate / 1.) DMF, 20 min, 2.) DMF, RT, 18 h

4: H₂ / 5percent Pd/C / methanol / 18 h / 1292.9 Torr

5: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, 2 h

6: 94.8 percent / 1N HCl, trifluoroacetic acid / 55 °C

7: sodium dithionite / dimethylformamide; H₂O / 0.5 h

8: 0.1N NaOH / 1.5 h

9: Me₂SO / dimethylformamide / 47 h

10: 0.1N NaOH / acetonitrile

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium dithionite; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm00141a010

Reference yield:

: 78520-75-9
1-azido-4-(p-carboxyphenoxy)-2-butanone ethylene ketal

: 78520-72-6
4-amino-4-deoxy-11-oxahomoaminopterin

Guidance literature:: Multi-step reaction with 8 steps

1: N-methylmorpholine, isobutyl chloroformate / 1.) DMF, 20 min, 2.) DMF, RT, 18 h

2: H₂ / 5percent Pd/C / methanol / 18 h / 1292.9 Torr

3: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, 2 h

4: 94.8 percent / 1N HCl, trifluoroacetic acid / 55 °C

5: sodium dithionite / dimethylformamide; H₂O / 0.5 h

6: 0.1N NaOH / 1.5 h

7: Me₂SO / dimethylformamide / 47 h

8: 0.1N NaOH / acetonitrile

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium dithionite; hydrogen; dimethyl sulfoxide; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00141a010