Pyridine, 2,3,4,5-tetrahydro-6-(methylthio)-

Base Information

• Chemical Name: Pyridine, 2,3,4,5-tetrahydro-6-(methylthio)-
• CAS No.: 19766-29-1
• Molecular Formula: C6H11NS
• Molecular Weight: 129.226
• DSSTox Substance ID: DTXSID50173455
• Nikkaji Number: J66.613K
• Wikidata: Q83043519
• Mol file: 19766-29-1.mol

Synonyms:2,3,4,5-Tetrahydro-6-(methylthio)pyridine;Pyridine, 2,3,4,5-tetrahydro-6-(methylthio)-;19766-29-1;BRN 0105991;5-21-01-00200 (Beilstein Handbook Reference);SCHEMBL7395015;DTXSID50173455;LS-132037;6-(methylsulfanyl)-2,3,4,5-tetrahydropyridine

Chemical Property of Pyridine, 2,3,4,5-tetrahydro-6-(methylthio)-

Chemical Property:

• Vapor Pressure: 1mmHg at 25°C
• Boiling Point: 184.4°Cat760mmHg
• Flash Point: 65.3°C
• Density: 1.08g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 129.06122053
• Heavy Atom Count: 8
• Complexity: 98.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CSC1=NCCCC1

Technology Process of Pyridine, 2,3,4,5-tetrahydro-6-(methylthio)-

There total 9 articles about Pyridine, 2,3,4,5-tetrahydro-6-(methylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Cyclopentanon-dimethyldithioacetal (56253-71-5) → 6-methylsulfanyl-2,3,4,5-tetrahydro-pyridine (19766-29-1)

Guidance literature:

With diazidotin dichloride; tin(IV) chloride; In dichloromethane; -78 deg C -> room temperature;

DOI:10.1021/ja00547a019

Reference yield: 5.0%

cyclopentanone oxime tosylate (10442-97-4) + diisobutylaluminum methanethiolate (85027-96-9) → 6-methylsulfanyl-2,3,4,5-tetrahydro-pyridine (19766-29-1)

Guidance literature:

In hexane; dichloromethane; at 40 ℃; for 0.1h;

DOI:10.1021/ja00347a052

Reference yield:

piperidine-2-thione (13070-01-4) + methyl iodide (74-88-4) → 6-methylsulfanyl-2,3,4,5-tetrahydro-pyridine (19766-29-1)

Guidance literature:

With benzene;

upstream raw materials:

piperidine-2-thione

acetone

methyl iodide

3,4,5,6-tetrahydro-pyridine-2-thiol

Downstream raw materials:

{4-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-phenyl}-(3,4,5,6-tetrahydro-pyridin-2-yl)-amine

1-benzoyl-1,4,5,6-tetrahydro-2-(methylthio)pyridine

1-acetyl-1,4,5,6-tetrahydro-2-(methylthio)pyridine

lupinine