N-(3,4,5-trimethoxybenzyl)cyclopropanamine

Base Information

• Chemical Name: N-(3,4,5-trimethoxybenzyl)cyclopropanamine
• CAS No.: 14471-17-1
• Molecular Formula: C13H19 N O3
• Molecular Weight: 237.2949
• Mol file: 14471-17-1.mol

Synonyms:Benzylamine,N-cyclopropyl-3,4,5-trimethoxy- (8CI); NSC 523291

Chemical Property of N-(3,4,5-trimethoxybenzyl)cyclopropanamine

Chemical Property:

• Vapor Pressure: 9.65E-05mmHg at 25°C
• Boiling Point: 338.7°C at 760 mmHg
• Flash Point: 140.2°C
• Density: 1.11g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3,4,5-trimethoxybenzyl)cyclopropanamine

There total 2 articles about N-(3,4,5-trimethoxybenzyl)cyclopropanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + Cyclopropylamine (765-30-0) → N-(3,4,5-trimethoxybenzyl)cyclopropanamine (14471-17-1)

Guidance literature:

3,4,5-trimethoxy-benzaldehyde; Cyclopropylamine; With acetic acid; In cis-1,2-Dichloroethylene; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In cis-1,2-Dichloroethylene; at 20 ℃; for 15h;

DOI:10.1021/acs.orglett.0c02385

Reference yield:

→ N-(3,4,5-trimethoxybenzyl)cyclopropanamine (14471-17-1)

Guidance literature:

Cyclopropylamin, 1) 3,4,5-Trimethoxy-benzaldehyd, Me., 2) Natriumboranat;

DOI:10.1021/jm00286a003

Reference yield: 95.0%

N-(3,4,5-trimethoxybenzyl)cyclopropanamine (14471-17-1) + 4-chloro-6-(2-(trimethylsilyl)ethoxy)nicotinic acid → 4-chloro-N-cyclopropyl-N-(3,4,5-trimethoxybenzyl)-6-(2-(trimethylsilyl)ethoxy)nicotinamide

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 3.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02385

upstream raw materials:

3,4,5-trimethoxy-benzaldehyde

Cyclopropylamine

Refernces