Pyrazolo(1,5-a)pyrimidin-7-amine, N-(2-(4-morpholinyl)ethyl)-5-propyl-6-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-

Base Information

• Chemical Name: Pyrazolo(1,5-a)pyrimidin-7-amine, N-(2-(4-morpholinyl)ethyl)-5-propyl-6-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
• CAS No.: 151327-04-7
• Molecular Formula: C29H33 N9 O
• Molecular Weight: 523.63
• DSSTox Substance ID: DTXSID20164759
• Wikidata: Q83033823
• Mol file: 151327-04-7.mol

Synonyms:151327-04-7;Pyrazolo(1,5-a)pyrimidin-7-amine, N-(2-(4-morpholinyl)ethyl)-5-propyl-6-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-;N-(2-morpholin-4-ylethyl)-5-propyl-6-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrazolo[1,5-a]pyrimidin-7-amine;SCHEMBL7314818;C29H33N9O;DTXSID20164759;TVDFPRLEYPSLOM-UHFFFAOYSA-N;C29-H33-N9-O;LS-129192

Chemical Property of Pyrazolo(1,5-a)pyrimidin-7-amine, N-(2-(4-morpholinyl)ethyl)-5-propyl-6-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 109.15000
• Density: 1.35g/cm³
• LogP: 3.87470
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 10
• Exact Mass: 523.28080671
• Heavy Atom Count: 39
• Complexity: 732

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1=NC2=CC=NN2C(=C1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)NCCN6CCOCC6

Technology Process of Pyrazolo(1,5-a)pyrimidin-7-amine, N-(2-(4-morpholinyl)ethyl)-5-propyl-6-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-

There total 3 articles about Pyrazolo(1,5-a)pyrimidin-7-amine, N-(2-(4-morpholinyl)ethyl)-5-propyl-6-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-[(2'-cyanobiphenyl-4-yl)methyl]-7-[2-(morpholin-4-yl)ethylamino]-5-propylpyrazolo[1,5-a]pyrimidine + trimethyltin azide (1118-03-2) → 7-[(N-Morpholinoethyl)amino]-5-propyl 6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)-methyl]pyrazolo[1,5-a]pyrimidine (151327-04-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate; acetonitrile;

Reference yield:

6-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxy-5-propylpyrazolo[1,5-a]pyrimidine (151326-96-4) → 7-[(N-Morpholinoethyl)amino]-5-propyl 6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)-methyl]pyrazolo[1,5-a]pyrimidine (151327-04-7)

Guidance literature:

Multi-step reaction with 3 steps

1: water; trichlorophosphate

2: ethanol; dichloromethane; water

3: triethylamine / tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate

With triethylamine; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; water; ethyl acetate; trichlorophosphate;

Reference yield:

Chloro 6-[(2'-cyanobiphenyl-4-yl)methyl]-5-propylpyrazolo[1,5-a]pyrimidine → 7-[(N-Morpholinoethyl)amino]-5-propyl 6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)-methyl]pyrazolo[1,5-a]pyrimidine (151327-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; dichloromethane; water

2: triethylamine / tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate

With triethylamine; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; water; ethyl acetate;

upstream raw materials:

trimethyltin azide

6-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxy-5-propylpyrazolo[1,5-a]pyrimidine

Refernces

• 1、 -. "Triazolopyrimidines which are angiotensin II receptor antagonists and pharmaceutical compositions in which they are present". . . Retrieved 2008/06/13.