7,8-Dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)(1,2,4)triazolo(1,5-b)pyridazine

Base Information

Chemical Name:7,8-Dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)(1,2,4)triazolo(1,5-b)pyridazine
CAS No.:152537-58-1
Molecular Formula:C₁₂H₁₉N₅O₃S
Molecular Weight:313.381
Hs Code.:
DSSTox Substance ID:DTXSID30165050
Nikkaji Number:J880.164I
Wikidata:Q83034191
Mol file:152537-58-1.mol

Synonyms:152537-58-1;7,8-Dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)(1,2,4)triazolo(1,5-b)pyridazine;1-Propanesulfonamide, 2,2-dimethyl-3-((7,8-dimethyl(1,2,4)triazolo(1,5-b)pyridazin-6-yl)oxy)-;2,2-Dimethyl-3-((7,8-dimethyl(1,2,4)triazolo(1,5-b)pyridazin-6-yl)oxy)-1-propanesulfonamide;3-[(7,8-dimethyl-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)oxy]-2,2-dimethylpropane-1-sulfonamide;3-[(4,5-dimethyl-1,2,7,9-tetrazabicyclo[4.3.0]nona-2,4,6,8-tetraen-3-y l)oxy]-2,2-dimethyl-propane-1;7,8-dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)[1,2,4]triazolo[1,5-b]pyridazine;SCHEMBL8316100;DTXSID30165050;LS-120920;2,2-Dimethyl-3-(7,8-dimethyl[1,2,4]triazolo[1,5-b]pyridazin-6-yloxy)propane-1-sulfonamide

Suppliers and Price of 7,8-Dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)(1,2,4)triazolo(1,5-b)pyridazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 7,8-Dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)(1,2,4)triazolo(1,5-b)pyridazine

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：120.85000
Density:1.42g/cm³
LogP:2.21570
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:313.12086066
Heavy Atom Count:21
Complexity:464

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NN2C1=NC=N2)OCC(C)(C)CS(=O)(=O)N)C

Technology Process of 7,8-Dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)(1,2,4)triazolo(1,5-b)pyridazine

There total 5 articles about 7,8-Dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)(1,2,4)triazolo(1,5-b)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51519-28-9
6-chloro-7,8-dimethyl-[1,2,4]triazolo[1,5-b]pyridazine

: methanol-dichloromethane

: 132115-56-1
3-hydroxy-2,2-dimethyl-1-propanesulfonamide

: 152537-58-1
7,8-dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)[1,2,4]triazolo[1,5-b]pyridazine

Guidance literature:: With sodium chloride; In N-methyl-acetamide; water;

Reference yield:

: 76593-36-7
3-amino-6-chloro-4,5-dimethylpyridazine

: 152537-58-1
7,8-dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)[1,2,4]triazolo[1,5-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: toluene

2: 1.) NH₂OH*HCl, 2.) polyphosphoric acid

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 18 h

With PPA; hydroxylamine hydrochloride; sodium hydride; In toluene;
DOI:10.1248/cpb.45.1447

Reference yield:

: 51519-08-5
N'-(6-chloro-4,5-dimethyl-pyridazin-3-yl)-N,N-dimethyl-formamidine

: 152537-58-1
7,8-dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)[1,2,4]triazolo[1,5-b]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NH₂OH*HCl, 2.) polyphosphoric acid

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 18 h

With PPA; hydroxylamine hydrochloride; sodium hydride;
DOI:10.1248/cpb.45.1447