7-Bromo-1-tetralone

Base Information

• Chemical Name: 7-Bromo-1-tetralone
• CAS No.: 32281-97-3
• Molecular Formula: C10H9BrO
• Molecular Weight: 225.085
• Hs Code.: 29147000
• Mol file: 32281-97-3.mol

Synonyms:7-Bromo-1,2,3,4-Tetrahydronaphthalen-1-one;7-Bromo-3,4-dihydro-1(2H)-naphthalenone;7-Bromo-3,4-dihydro-2H-naphthalen-1-one;NSC 74917;

Chemical Property of 7-Bromo-1-tetralone

Chemical Property:

• Appearance/Colour: Yellow solid
• Vapor Pressure: 0.000548mmHg at 25°C
• Melting Point: 78 °C
• Refractive Index: 1.598
• Boiling Point: 311.9 °C at 760 mmHg
• Flash Point: 103.5 °C
• PSA: 17.07000
• Density: 1.511 g/cm³
• LogP: 2.96810
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

7-Bromo-1-tetralone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 7-Bromo-1-tetralone

There total 18 articles about 7-Bromo-1-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(4-bromophenyl)butanoic acid (35656-89-4) → 7-bromo-3,4-dihydro-2H-naphthalen-1-one (32281-97-3)

Guidance literature:

With PPA; at 90 ℃; for 0.25h;

DOI:10.1021/jo00027a063

Reference yield: 95.0%

7-bromo-1,2,3,4-tetrahydronaphthalen-1-ol (75693-15-1) → 7-bromo-3,4-dihydro-2H-naphthalen-1-one (32281-97-3)

Guidance literature:

With acetic acid; 1,1'-(phenyl-l3-iodanediyl)bis(pyridinium)trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 60 ℃; for 1.5h; chemoselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/acs.orglett.9b02018

Reference yield: 84.0%

4-(4-bromophenyl)-butyryl chloride (6628-03-1) → 7-bromo-3,4-dihydro-2H-naphthalen-1-one (32281-97-3)

Guidance literature:

With Fe-Al-MCM-41 molecular sieve; In toluene; at 60 ℃; for 18h; Green chemistry;

upstream raw materials:

4-(4-bromophenyl)-butyryl chloride

4-(4-bromophenyl)butanoic acid

3,4-dihydronaphthalene-1(2H)-one

bromobenzene

Downstream raw materials:

2,12-Dibromo-7-phenyl-5,6,8,9-tetrahydrodibenzacridine

7-benzylidene-2-bromo-α-tetralone

2-(2-cyano-3,4-dihydronaphthalen-7-yl)-5-(4-cyanophenyl)furan

(8-bromo-5,6-dihydro-naphthalen-2-yl)-triphenyl-silane

Refernces

• 1、 Hosoya, Takamitsu,Karaki, Fumika,Minami, Yasunori,Nishiyama, Yoshitake,Sakata, Yuki,Tamura, Yuya,Yoshida, Suguru. "Synthesis of multisubstituted cycloalkenes through carbomagnesiation of strained cycloalkynes". supporting information. p. 7147 - 7150. Retrieved 2020/07/21.
• 2、 Shen, Jiaxuan,Li, Nannan,Yu, Yanjiang,Ma, Chunhua. "Visible-light-induced oxidation/[3 + 2] cycloaddition/oxidative aromatization to construct benzo[ a]carbazoles from 1,2,3,4-tetrahydronaphthalene and arylhydrazine hydrochlorides". supporting information. p. 7179 - 7183. Retrieved 2019/09/30.