4-(4-BROMOPHENYL)BUTANOIC ACID

Base Information

• Chemical Name: 4-(4-BROMOPHENYL)BUTANOIC ACID
• CAS No.: 35656-89-4
• Molecular Formula: C10H11BrO2
• Molecular Weight: 243.1
• Hs Code.: 29163990
• Mol file: 35656-89-4.mol

Synonyms:Butyricacid, 4-(p-bromophenyl)- (7CI);4-(p-Bromophenyl)butyric acid;NSC 74918;

Chemical Property of 4-(4-BROMOPHENYL)BUTANOIC ACID

Chemical Property:

• Vapor Pressure: 1.57E-05mmHg at 25°C
• Melting Point: 67 °C
• Refractive Index: 1.567
• Boiling Point: 351.05 °C at 760 mmHg
• PKA: 4.74±0.10(Predicted)
• Flash Point: 166.11 °C
• PSA: 37.30000
• Density: 1.464 g/cm³
• LogP: 2.85640
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(4-Bromophenyl)butanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-BROMOPHENYL)BUTANOIC ACID

There total 17 articles about 4-(4-BROMOPHENYL)BUTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-oxo-4-(4-bromophenyl)butanoic acid (6340-79-0) → 4-(4-bromophenyl)butanoic acid (35656-89-4)

Guidance literature:

With potassium hydroxide; hydrazine; In 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; at 200 ℃; for 2h;

DOI:10.1021/ja004279v

Reference yield:

4-oxo-4-(4-bromophenyl)butanoic acid (6340-79-0) → 4-(4-bromophenyl)butanoic acid (35656-89-4) + 4-Phenylbutyric acid (1821-12-1)

Guidance literature:

With hydrogenchloride; amalgamated zinc; toluene; weiteres Reagens: Essigsaeure;

DOI:10.1021/ja01268a051

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 4-oxo-4-(4-bromophenyl)butanoic acid (6340-79-0) + acetic acid (64-19-7,77671-22-8) + toluene (108-88-3,15644-74-3,16713-13-6) → 4-(4-bromophenyl)butanoic acid (35656-89-4) + 4-Phenylbutyric acid (1821-12-1)

Guidance literature:

DOI:10.1021/ja01268a051

upstream raw materials:

4-oxo-4-(4-bromophenyl)butanoic acid

hydrogenchloride

acetic acid

toluene

Downstream raw materials:

7-bromo-3,4-dihydro-2H-naphthalen-1-one

4-(4-bromophenyl)butanoic acid methyl ester

γ-(4-bromophenyl)-γ-butyrolactone

1-bromo-4-(3-chloropropyl)benzene

Refernces

• 1、 Chen, Hui,Zhao, Sihan,Cheng, Shaobing,Dai, Xingjie,Xu, Xiaoying,Yuan, Weicheng,Zhang, Xiaomei. "Synthesis of Novel Pterocarpen Analogues via [3?+?2] Coupling-Elimination Cascade of α,α-Dicyanoolefins with Quinone Monoimines". . p. 1672 - 1683. Retrieved 2019/04/08.
• 2、 Betori, Rick C.,May, Catherine M.,Scheidt, Karl A.. "Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations". supporting information. p. 16490 - 16494. Retrieved 2019/11/03.