4-Methyl-2-(piperidin-1-yl)quinoline

Base Information

Chemical Name:4-Methyl-2-(piperidin-1-yl)quinoline
CAS No.:5465-86-1
Molecular Formula:C15H18N2
Molecular Weight:226.3168
Hs Code.:
European Community (EC) Number:803-730-5
NSC Number:25850
DSSTox Substance ID:DTXSID30282438
Nikkaji Number:J1.448.797B
Wikidata:Q27086998
Pharos Ligand ID:D542XBJD6YZL
ChEMBL ID:CHEMBL1459962
Mol file:5465-86-1.mol

Synonyms:ML 204;ML-204;ML204 cpd

Suppliers and Price of 4-Methyl-2-(piperidin-1-yl)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ML 204
10mg
$ 423.00

Usbiological
ML204
100mg
$ 1380.00

Usbiological
ML 204
10mg
$ 403.00

TRC
4-Methyl-2-(1-piperidinyl)-quinoline
100mg
$ 195.00

Tocris
ML204 ≥99%(HPLC)
50
$ 682.00

Tocris
ML204 ≥99%(HPLC)
10
$ 162.00

Sigma-Aldrich
ML204 ≥98% (HPLC)
5mg
$ 106.00

Sigma-Aldrich
ML204 ≥98% (HPLC)
25mg
$ 423.00

Medical Isotopes, Inc.
4-Methyl-2-(1-piperidinyl)-quinoline
25 mg
$ 675.00

DC Chemicals
ML204 >98%
100 mg
$ 300.00

Total 16 raw suppliers

Chemical Property of 4-Methyl-2-(piperidin-1-yl)quinoline

Chemical Property:

Vapor Pressure:9.5E-07mmHg at 25°C
Melting Point:72-73 °C
Boiling Point:404.4°Cat760mmHg
PKA:7.34±0.61(Predicted)
Flash Point:198.3°C
PSA：16.13000
Density:1.102g/cm³
LogP:3.59850
Storage Temp.:2-8°C
Solubility.:DMSO: soluble5mg/mL at warmed (clear solution)
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:226.146998583
Heavy Atom Count:17
Complexity:247

Purity/Quality:

99%, ^*data from raw suppliers

ML 204 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=NC2=CC=CC=C12)N3CCCCC3
Description ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.
Uses 4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation, muscle response due to interaction with the environment. 4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation and muscle response due to interaction with the environment.

Technology Process of 4-Methyl-2-(piperidin-1-yl)quinoline

There total 11 articles about 4-Methyl-2-(piperidin-1-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 110-89-4
piperidine

: 634-47-9
2-chloro-4-methylquinoline

: 5465-86-1
ML 204

Guidance literature:: With aluminum oxide; for 0.0333333h; microwave irradiation;
DOI:10.1080/00397910008087076

Reference yield: 82.0%

: 4053-40-1
4-methylquinoline 1-oxide

: 5542-49-4
piperidin-1-yl benzoate

: 5465-86-1
ML 204

Guidance literature:: With potassium carbonate; 1,2-dichloro-ethane; copper(l) chloride; at 80 ℃; for 10h; Sealed tube;
DOI:10.1002/ejoc.201800963