1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-4-oxo-, monohydrochloride

Base Information

Chemical Name:1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-4-oxo-, monohydrochloride
CAS No.:79286-76-3
Molecular Formula:C₁₅H₁₇FN₄O₃*ClH
Molecular Weight:356.784
Hs Code.:
DSSTox Substance ID:DTXSID201000372

Synonyms:79286-76-3;1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-4-oxo-, monohydrochloride;C15H17FN4O3.ClH;SCHEMBL1231132;ZLUCAEFRANXBKF-UHFFFAOYSA-N;DTXSID201000372;C15-H17-F-N4-O3.Cl-H;LS-95927;7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride;7-(3-Aminopyrrolidin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid--hydrogen chloride (1/1)

Suppliers and Price of 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-4-oxo-, monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-4-oxo-, monohydrochloride

Chemical Property:

Vapor Pressure:2.34E-13mmHg at 25°C
Boiling Point:559.6°C at 760 mmHg
Flash Point:292.2°C
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:356.1051463
Heavy Atom Count:24
Complexity:541

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1C=C(C(=O)C2=CC(=C(N=C21)N3CCC(C3)N)F)C(=O)O.Cl

Technology Process of 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-4-oxo-, monohydrochloride

There total 5 articles about 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-4-oxo-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 79286-93-4
ethyl 7-(3-acetylamino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

: 79286-76-3
7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; Heating;
DOI:10.1021/jm00378a004

Reference yield:

: 79286-75-2
7-(3-acetylamino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

: 79286-76-3
7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride

Guidance literature:: In hydrogenchloride; ethanol;

Reference yield:

: 79286-73-0
1-ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloro-1,8-naphthyridine-3-carboxylic acid

: 79286-76-3
7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ethyl chlorocarbonate, Et₃N / 1.) CHCl₃, 5 to 10 deg C, 30 min, 2.) CHCl₃, RT, 4 h

2: 90 percent / Et₃N / ethanol / Heating

3: 84 percent / aq. HCl / Heating

With hydrogenchloride; chloroformic acid ethyl ester; triethylamine; In ethanol;
DOI:10.1021/jm00378a004