4-Ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methyl-5-pyrimidinecarboxamide

Base Information

Chemical Name:4-Ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methyl-5-pyrimidinecarboxamide
CAS No.:84332-33-2
Molecular Formula:C₁₅H₂₄N₄O₂
Molecular Weight:292.381
Hs Code.:2933990090
DSSTox Substance ID:DTXSID601004633
Nikkaji Number:J70.345A
Mol file:84332-33-2.mol

Synonyms:84332-33-2;BRN 0960770;4-Ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methyl-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 4-ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methyl-;4-ethoxy-n-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methyl-5-pyrimidinecarboxamide;SCHEMBL1014023;DTXSID601004633;LS-134810;4-Ethoxy-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methylpyrimidine-5-carboximidic acid;5-Pyrimidinecarboxamide,4-ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methyl-

Suppliers and Price of 4-Ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methyl-5-pyrimidinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-PYRIMIDINECARBOXAMIDE, 4-ETHOXY-N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-2-METHYL- 95.00%
5MG
$ 496.76

Total 3 raw suppliers

Chemical Property of 4-Ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methyl-5-pyrimidinecarboxamide

Chemical Property:

Vapor Pressure:2.21E-08mmHg at 25°C
Boiling Point:452.6°C at 760 mmHg
Flash Point:227.5°C
PSA：70.84000
Density:1.097g/cm³
LogP:1.91050
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:292.18992602
Heavy Atom Count:21
Complexity:340

Purity/Quality:: 5-PYRIMIDINECARBOXAMIDE, 4-ETHOXY-N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-2-METHYL- 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1CCCC1CNC(=O)C2=CN=C(N=C2OCC)C

Technology Process of 4-Ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methyl-5-pyrimidinecarboxamide

There total 4 articles about 4-Ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methyl-5-pyrimidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2134-36-3
ethyl 4-chloro-2-methylpyrimidine-5-carboxylate

: 84332-33-2
4-ethoxy-2-methyl-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / sodium / Ambient temperature

2: NaOH / methanol; H₂O / 1 h / 65 °C

3: 1.) triethylamine, ethylchloroformate / 1.)THF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 7389-16-4
4-ethoxy-2-methyl-pyrimidine-5-carboxylic acid ethyl ester

: 84332-33-2
4-ethoxy-2-methyl-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.)THF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 26116-12-1
1-ethyl-2-pyrrolidinemethanamine

: 72411-81-5
2-methyl-4-ethoxy-5-pyrimidinyl carboxylic acid

: 84332-33-2
4-ethoxy-2-methyl-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1.)THF, 0 deg C, 30 min, 2.) room temp. overnight;