26116-12-1

Basic information

• Product Name: 2-(Aminomethyl)-1-ethylpyrrolidine
• Synonyms: (1-Ethyl-2-pyrrolidinyl)methanamine;1-Ethyl-2-(aminomethyl)pyrrolidine;1-Ethyl-2-pyrrolidinemethylamine;2-(Aminomethyl)-N-ethylpyrrolidine;Pyrrolidine, 2-(aminomethyl)-1-ethyl-;1-ethylpyrrolidin-2-ylmethylamine;2-(AMINOMETHYL)-1-ETHYLPYRROLIDINE;2-PYRROLIDINEMETHANAMINE, 1-ETHYL-, (2S)-
• CAS NO: 26116-12-1
• Molecular Formula: C₇H₁₆N₂
• Molecular Weight: 128.22
• EINECS: 247-466-3
• Product Categories: API intermediates;Building Blocks;Heterocyclic Building Blocks;Pyrrolidines;Piperidines
• Mol File: 26116-12-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 58-60 °C16 mm Hg(lit.)
• Flash Point: 135 °F
• Appearance: Clear yellow/Liquid
• Density: 0.884 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.22mmHg at 25°C
• Refractive Index: n20/D 1.4670(lit.)
• Storage Temp.: 2-8°C
• PKA: 10.04±0.40(Predicted)
• CAS DataBase Reference: 2-(Aminomethyl)-1-ethylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Aminomethyl)-1-ethylpyrrolidine(26116-12-1)
• EPA Substance Registry System: 2-(Aminomethyl)-1-ethylpyrrolidine(26116-12-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 26116-12-1(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow liquid

InChI:InChI=1/C7H16N2/c1-2-9-5-3-4-7(9)6-8/h7H,2-6,8H2,1H3/p+2/t7-/m0/s1

Upstream product

• 2167-11-5 3-Chloro-1-ethylpiperidine 
• 87-69-4 tartaric acid 
• 98-01-1 furfural 
• 1708-41-4 2-(furan-2-yl)-1,3-dioxolane 
• 2167-14-8 1-ethyl-1H-pyrrole-2-carbaldehyde 
• 533-88-0 2-amino-5-hydroxyvaleric acid 
• 1224637-01-7 1-ethylpyrrolidine-2-carboxamide 
• 57796-50-6 5-allylamino-6-chloro-3-methoxy-pyrazine-2-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide 
• 57796-49-3 5-benzylamino-6-chloro-3-methoxy-pyrazine-2-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide 
• 57826-83-2 6-chloro-3,5-dimethoxy-pyrazine-2-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide 
• 57796-48-2 N-(1-ethylpyrrolidin-2-ylmethyl)-6-chloro-3-methoxy-5-methylthiopyrazine-2-carboxamide 
• 498-63-5 2-hydroxymethylpyrrolidine 
• 54385-06-7 1-acetyl-2-chloromethyl-pyrrolidine 
• 27822-68-0 N-acetylprolinol 

Downstream Products

• 64858-76-0 2-(1-Ethyl-pyrrolidin-2-ylmethyl)-isoindole-1,3-dione 
• 184637-53-4 2-<<(3,4-dichlorophenyl)acetamido>methyl>-1-ethylpyrrolidine 
• 23694-03-3 N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-5-nitrobenzamide 
• 103595-63-7 N-((Ethyl-1 pyrrolidinyl-2)methyl) trimethoxy-2,3,4 benzensulfonamide HCl 
• 15676-16-1 N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide 
• 133129-46-1 (R)-N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 133129-46-1 (R)-N-((R)-1-Ethyl-pyrrolidin-2-ylmethyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 120690-12-2 N-<(1-ethylpyrrolidin-2-yl)methyl>-4-fluorobenzamide 
• 126396-89-2 (2-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-(1-ethyl-pyrrolidin-2-ylmethyl)-amine 
• 138761-19-0 4-Chloro-pyridine-3-sulfonic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide 
• 84225-77-4 3-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,6-dimethoxy-benzamide 
• 82935-27-1 A 32637 
• 72418-32-7 N-(N-ethylpyrrolidin-2-ylmethyl)-4-isopropoxy-2-amino-5-pyrimidinecarboxamide 
• 72418-31-6 2-Amino-4-propoxy-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide 

Relevant articles and documents

Preparation method of (s)-N-ethyl-2-aminomethylpyrrolidine

The invention provides a preparation method of (s)-N-ethyl-2-aminomethylpyrrolidine. 2-amino-5-hydroxyvaleric acid used as a raw material undergoes esterification protection to obtain methyl 2-amino-5-hydroxypentanoate, N-ethylation is further achieved through bromoethane, and then the N-ethyl-2-aminomethylpyrrolidine is prepared through hydroxyl halogenation, substitution cyclization, ammonolysisand reduction six-step reaction. High-cost raw materials and an N,O-diethylation reaction are successfully avoided, and the method has the advantages of easiness in implementation of the above reaction route, few byproducts, high yield reaching 64.2%, and suitableness for industrialization.

SUBSTITUTED BENZAMIDE MODULATORS OF DOPAMINE RECEPTOR

The present invention relates to new substituted benzamide modulators of dopamine receptor, pharmaceutical compositions thereof, and methods of use thereof.

4-unsubstituted dihydroisoquinolinone derivatives and combinatorial libraries thereof

The present invention relates to novel dihydroisoquinolinone (DHQ) derivative compounds of the following formula: wherein R1to R7, X, Y, Z, b, c and d have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing DHQ derivative compounds.