Cyproheptadine

Base Information

Chemical Name:Cyproheptadine
CAS No.:129-03-3
Molecular Formula:C21H21 N
Molecular Weight:287.404
Hs Code.:29143900
European Community (EC) Number:204-928-9,623-762-1
UNII:2YHB6175DO
DSSTox Substance ID:DTXSID8022872
Nikkaji Number:J5.419D
Wikipedia:Cyproheptadine
Wikidata:Q417884
NCI Thesaurus Code:C61695
RXCUI:3013
Pharos Ligand ID:W5YGQF7BFF6K
Metabolomics Workbench ID:42791
ChEMBL ID:CHEMBL516
Mol file:129-03-3.mol

Synonyms:Antergan;Cyproheptadine;Dihexazin;Periactin;Peritol;Viternum

Suppliers and Price of Cyproheptadine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Cycloheptadine
250mg
$ 550.00

Medical Isotopes, Inc.
Cyproheptadine
25 mg
$ 1500.00

Crysdot
4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine 95+%
1g
$ 743.00

Cayman Chemical
Cyproheptadine ≥98%
1g
$ 215.00

Cayman Chemical
Cyproheptadine ≥98%
500mg
$ 156.00

Cayman Chemical
Cyproheptadine ≥98%
250mg
$ 88.00

Cayman Chemical
Cyproheptadine ≥98%
100mg
$ 39.00

Biorbyt Ltd
Cyproheptadine
100 μg
$ 635.80

Biorbyt Ltd
Cyproheptadine
50 μg
$ 425.00

Biorbyt Ltd
Cyproheptadine
500 μg
$ 957.10

Total 64 raw suppliers

Chemical Property of Cyproheptadine

Chemical Property:

Appearance/Colour:Colorless liquid, sweet, almond odor.
Vapor Pressure:6.03E-08mmHg at 25°C
Melting Point:112.3-113.3°
Refractive Index:1.8240 (estimate)
Boiling Point:440.1°Cat760mmHg
PKA:pKa 8.87 (Uncertain)
Flash Point:194.5°C
PSA：3.24000
Density:1.115g/cm³
LogP:5.43780
Water Solubility.:317.6ug/L(22.5 oC)
XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:287.167399674
Heavy Atom Count:22
Complexity:423

Purity/Quality:

99%, ^*data from raw suppliers

Cycloheptadine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antihistamines
Canonical SMILES:CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1
Recent ClinicalTrials:Noninvasive Markers of Functional Nausea in Children
Description Cyproheptadine has antianaphylactic activity that is associated with its ability to slow down the release of histamine and other mediators from fat cells.
Uses Antihistaminic; antipruritic. It is mainly used for treating bronchial asthma attacks, allergic bronchitis, rhinitis, and allergic skin reactions as well as in adjuvant therapy for anaphylactic reactions. Synonyms of this drug are periactin and vimicon.
Therapeutic Function Antipruritic, Antihistaminic, Appetite stimulant

Technology Process of Cyproheptadine

There total 6 articles about Cyproheptadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol

: 129-03-3
cyproheptadine

Guidance literature:: With formic acid; at 100 ℃; for 2h;
DOI:10.1021/jo100563p

Reference yield:

: 2222-33-5
dibenzosuberenon

: 129-03-3
cyproheptadine

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / tetrahydrofuran / 70 °C

2: 83 percent / HOAc, conc. HCl / 2 h / 120 °C

With hydrogenchloride; acetic acid; In tetrahydrofuran;
DOI:10.1002/ardp.19963290206

Reference yield:

: 121138-82-7
ethyl 4-(5H-dibenzocyclohepten-5-ylidene)-1-piperidinecarboxylate

: 129-03-3
cyproheptadine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Yield given; Heating;
DOI:10.1016/S0040-4020(01)89809-4