3-Methoxybenzo[b]thiophene-2-carboxylic acid

Base Information

• Chemical Name: 3-Methoxybenzo[b]thiophene-2-carboxylic acid
• CAS No.: 19354-50-8
• Molecular Formula: C10H8 O3 S
• Molecular Weight: 208.238
• Hs Code.: 2934999090
• European Community (EC) Number: 242-987-2
• UNII: PRT84LK3C5
• DSSTox Substance ID: DTXSID50172963
• Nikkaji Number: J242.781H
• Wikidata: Q83043050
• Mol file: 19354-50-8.mol

Synonyms:3-Methoxybenzo[b]thiophene-2-carboxylic acid;19354-50-8;3-methoxy-1-benzothiophene-2-carboxylic acid;3-Methoxybenzo(b)thiophene-3-carboxylic acid;PRT84LK3C5;EINECS 242-987-2;3-METHOXYBENZO[B]THIOPHENE-3-CARBOXYLIC ACID;3-Methoxybenzo(b)thiophene-2-carboxylic acid;UNII-PRT84LK3C5;SCHEMBL1098130;DTXSID50172963;AKOS022625330;methoxybenzo[b]thiophene carboxylic acid;3-Methoxy benzothiophene 2-carboxylic acid;3-Methoxybenzo[b]thiophene-2-carboxylicacid;CS-0227025;FT-0733017;A880257;BENZO(B)THIOPHENE-2-CARBOXYLIC ACID, 3-METHOXY-

Chemical Property of 3-Methoxybenzo[b]thiophene-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 5.59E-07mmHg at 25°C
• Boiling Point: 395.9°Cat760mmHg
• Flash Point: 193.3°C
• PSA: 74.77000
• Density: 1.392g/cm³
• LogP: 2.60810
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 208.01941529
• Heavy Atom Count: 14
• Complexity: 231

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxybenzo[b]thiophene-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(SC2=CC=CC=C21)C(=O)O

Technology Process of 3-Methoxybenzo[b]thiophene-2-carboxylic acid

There total 11 articles about 3-Methoxybenzo[b]thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 3-methoxybenzothiophene-2-carboxylate (19354-51-9) → 3-methoxy-1-benzothiophene-2-carboxylic acid (19354-50-8)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1071/CH14055

Reference yield:

methyl 3-hydroxy benzothiophene-2-carboxylate (10.4 g)dimethyl sulphate + methyl 2-nitrobenzoate (606-27-9) + Methyl thioglycolate (2365-48-2) → 3-methoxy-1-benzothiophene-2-carboxylic acid (19354-50-8)

Guidance literature:

With lithium hydroxide; sodium hydroxide; potassium carbonate; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

methyl 3-hydroxybenzo[b]thiophene-2-carboxylate (13134-76-4) → 3-methoxy-1-benzothiophene-2-carboxylic acid (19354-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C

2: lithium hydroxide monohydrate / water; methanol / 5 h / 75 °C

With lithium hydroxide monohydrate; potassium carbonate; In methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

methyl 2-nitrobenzoate

Methyl thioglycolate

methyl 3-methoxybenzothiophene-2-carboxylate

(E)-3-phenylacrylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 19354-50-8 3-methoxybenzo[b]thiophene-3-carboxylic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send