1H-Pyrrolo3,2-fquinoline-2-carboxylic acid, 8-chloro-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)-

Base Information

• Chemical Name: 1H-Pyrrolo3,2-fquinoline-2-carboxylic acid, 8-chloro-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)-
• CAS No.: 118292-35-6
• Molecular Formula: C₂₆H₂₆ClN₃O₈
• Molecular Weight: 543.961
• Hs Code.: 2933499090
• Mol file: 118292-35-6.mol

Synonyms:1H-Pyrrolo[3,2-f]quinoline-2-carboxylicacid,8-chloro-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-,methyl ester, (2R-trans)-; Antibiotic DC 89A1; Antibiotic SF 2582B; DuocarmycinC1; Pyrindamycin B; SF 2582B

Chemical Property of 1H-Pyrrolo3,2-fquinoline-2-carboxylic acid, 8-chloro-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)-

Chemical Property:

• Boiling Point: 810.5°Cat760mmHg
• PKA: 8.79±0.60(Predicted)
• Flash Point: 444°C
• PSA: 139.42000
• Density: 1.52g/cm³
• LogP: 3.45250

Purity/Quality:

98.5% ^*data from raw suppliers

6-Chloro-2-hydroxyquinoline-4-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo3,2-fquinoline-2-carboxylic acid, 8-chloro-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)-

There total 2 articles about 1H-Pyrrolo3,2-fquinoline-2-carboxylic acid, 8-chloro-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (2R,8S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Duocarmycin A (118292-34-5,132436-57-8,132436-58-9,149405-55-0,149405-58-3,149405-59-4) → Duocarmycin C2 (128517-09-9,134233-12-8) + Duocarmycin C1 (118292-35-6,113189-05-2)

Guidance literature:

With hydrogenchloride; In acetone;

DOI:10.1248/cpb.36.3728

Reference yield:

duocarmycin A (118292-34-5) → duocarmycin C2 (118292-36-7) + duocarmycin C1 (118292-35-6,113189-05-2)

Guidance literature:

With hydrogenchloride; In acetone; for 0.0166667h;

DOI:10.1248/cpb.43.378

Reference yield: 72.0%

duocarmycin C1 (118292-35-6,113189-05-2) → 5,6,7-trimethoxy-1H-indole-2-carboxylic acid methyl ester (118292-37-8) + 2,4-Dihydroxy-2-methyl-2,3-dihydro-pyrrolo[3,2-f]quinolin-1-one + C13H14N2O3

Guidance literature:

With potassium hydroxide; In methanol; at 80 ℃; for 0.166667h;

DOI:10.1248/cpb.43.378

upstream raw materials:

Duocarmycin A

duocarmycin A

Downstream raw materials:

5,6,7-trimethoxy-1H-indole-2-carboxylic acid methyl ester

4-Hydroxy-2-methyl-1-oxo-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline-2-carboxylic acid methyl ester