Technology Process of (3R,5S,5'aR)-5-(3-Furyl)-3',4,5,5',5'aα,7',8',8'aα-octahydro-7'α-methylspiro[furan-3(2H),6'-[6H]naphtho[1,8-bc]furan]-2,2'(4'H)-dione
There total 10 articles about (3R,5S,5'aR)-5-(3-Furyl)-3',4,5,5',5'aα,7',8',8'aα-octahydro-7'α-methylspiro[furan-3(2H),6'-[6H]naphtho[1,8-bc]furan]-2,2'(4'H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-bromofurane;
With
n-butyllithium;
In
diethyl ether; hexane;
at -78 ℃;
for 0.5h;
C16H20O5;
In
diethyl ether; hexane;
at -78 ℃;
for 0.333333h;
stereoselective reaction;
DOI:10.1021/ol301098s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; tert-butyl alcohol / 1 h / 0 - 20 °C
2.1: potassium hydroxide / diethyl ether; water / 0.5 h / 0 °C
3.1: ozone / dichloromethane / 0.17 h / -78 °C
3.2: 12 h / 325 °C
4.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C
4.2: 0.33 h / -78 °C
With
sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; ozone; potassium hydroxide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol;
1.1: Pinnick oxidation;
DOI:10.1021/ol301098s
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ozone / dichloromethane / 0.17 h / -78 °C
1.2: 12 h / 325 °C
2.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C
2.2: 0.33 h / -78 °C
With
n-butyllithium; ozone;
In
diethyl ether; hexane; dichloromethane;
DOI:10.1021/ol301098s
