Acetamide, 2-((2-aminoacetyl)amino)-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-

Base Information

Chemical Name:Acetamide, 2-((2-aminoacetyl)amino)-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-
CAS No.:74088-33-8
Molecular Formula:C17H15Cl2N3O3
Molecular Weight:380.2253
Hs Code.:
DSSTox Substance ID:DTXSID60995529
Wikidata:Q82986987

Synonyms:BRN 6000035;74088-33-8;Acetamide, 2-((2-aminoacetyl)amino)-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-;N-(4-Chloro-2-(2-chlorobenzoyl)phenyl)-glycylglycinamide;Glycinamide, N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-glycyl-;DTXSID60995529;LS-72176;2-Amino-N-{N-[4-chloro-2-(2-chlorobenzoyl)phenyl]glycyl}ethanimidic acid

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetamide, 2-((2-aminoacetyl)amino)-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-

Chemical Property:

Vapor Pressure:1.2E-16mmHg at 25°C
Boiling Point:647.4°Cat760mmHg
Flash Point:345.3°C
Density:1.423g/cm³
XLogP3:3.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:379.0490467
Heavy Atom Count:25
Complexity:504

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)C2=C(C=CC(=C2)Cl)NCC(=O)NC(=O)CN)Cl

Technology Process of Acetamide, 2-((2-aminoacetyl)amino)-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)-

There total 2 articles about Acetamide, 2-((2-aminoacetyl)amino)-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 74088-30-5
[({[4-Chloro-2-(2-chloro-benzoyl)-phenylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamic acid benzyl ester

: 74088-33-8
2-Amino-N-{[4-chloro-2-(2-chloro-benzoyl)-phenylcarbamoyl]-methyl}-acetamide

Guidance literature:: With hydrogen bromide; In acetic acid; for 1.5h; Ambient temperature;
DOI:10.1021/jm00181a013

Reference yield:

: 2958-36-3,53960-29-5
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

: 74088-33-8
2-Amino-N-{[4-chloro-2-(2-chloro-benzoyl)-phenylcarbamoyl]-methyl}-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HMPA, SOCl₂ / 1.) -5 deg C, 20 min, 2.) RT, overnight

2: 78 percent / 24percent HBr / acetic acid / 1.5 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; hydrogen bromide; In acetic acid;
DOI:10.1021/jm00181a013