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N,1-bis(2-phenylethyl)piperidine-4-carboxamide

Base Information
  • Chemical Name:N,1-bis(2-phenylethyl)piperidine-4-carboxamide
  • CAS No.:37969-07-6
  • Molecular Formula:C22H28N2O
  • Molecular Weight:336.4705
  • Hs Code.:
  • NSC Number:107294
  • DSSTox Substance ID:DTXSID20296049
  • Wikidata:Q82036366
  • Mol file:37969-07-6.mol
N,1-bis(2-phenylethyl)piperidine-4-carboxamide

Synonyms:37969-07-6;N,1-diphenethylpiperidine-4-carboxamide;NSC107294;DTXSID20296049;NSC-107294

Suppliers and Price of N,1-bis(2-phenylethyl)piperidine-4-carboxamide
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
Total 39 raw suppliers
Chemical Property of N,1-bis(2-phenylethyl)piperidine-4-carboxamide
Chemical Property:
  • Vapor Pressure:1.63E-11mmHg at 25°C 
  • Boiling Point:534.8°Cat760mmHg 
  • Flash Point:277.2°C 
  • Density:1.074g/cm3 
  • XLogP3:3.9
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:7
  • Exact Mass:336.220163521
  • Heavy Atom Count:25
  • Complexity:378
Purity/Quality:

98% *data from raw suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1CN(CCC1C(=O)NCCC2=CC=CC=C2)CCC3=CC=CC=C3
  • Use Description N,1-bis(2-phenylethyl)piperidine-4-carboxamide, also known as PPAP, is a chemical compound with applications in various fields. In the pharmaceutical industry, it serves as a precursor in the synthesis of novel drug compounds and pharmaceuticals, particularly those involved in the research and development of potential medications for neurological and psychiatric disorders. Its role is crucial in the structural modification of molecules, enabling the creation of new drug candidates with potential therapeutic properties. Additionally, in academic research, N,1-bis(2-phenylethyl)piperidine-4-carboxamide can be utilized as a building block for the synthesis of complex organic molecules, contributing to studies in organic chemistry and chemical biology. PPAP's versatility across these fields underscores its significance in advancing drug discovery, academic research, and the development of potential treatments for various medical conditions.
Technology Process of N,1-bis(2-phenylethyl)piperidine-4-carboxamide

There total 5 articles about N,1-bis(2-phenylethyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃; for 48h;
DOI:10.1021/jo010111w
Guidance literature:
Multi-step reaction with 4 steps
1: 87 percent / triethylamine / tetrahydrofuran; H2O / 20 °C
2: 81 percent / EDCI; HOBt; Et3N / CHCl3; dimethylformamide / 16 h / 20 °C
3: TFA / CH2Cl2 / 2.5 h / 20 °C
4: 62 percent / diisopropylethylamine / dimethylformamide / 48 h / 50 °C
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jo010111w
Guidance literature:
Multi-step reaction with 3 steps
1: 81 percent / EDCI; HOBt; Et3N / CHCl3; dimethylformamide / 16 h / 20 °C
2: TFA / CH2Cl2 / 2.5 h / 20 °C
3: 62 percent / diisopropylethylamine / dimethylformamide / 48 h / 50 °C
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo010111w
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