N-(2-phenylethyl)piperidine-4-carboxamide

Base Information

Chemical Name:N-(2-phenylethyl)piperidine-4-carboxamide
CAS No.:37978-09-9
Molecular Formula:C14H20N2O
Molecular Weight:232.326
Hs Code.:2933399090
DSSTox Substance ID:DTXSID80358273
Wikidata:Q82138733
Mol file:37978-09-9.mol

Synonyms:N-(2-phenylethyl)piperidine-4-carboxamide;37978-09-9;N-phenethylpiperidine-4-carboxamide;Cambridge id 6578104;SCHEMBL4034002;DTXSID80358273;STK055303;AKOS000125684;CS-0362559;AB00110797-01;A1-21365

Suppliers and Price of N-(2-phenylethyl)piperidine-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N-(2-PHENYLETHYL)PIPERIDINE-4-CARBOXAMIDE 95.00%
5G
$ 1722.11

A1 Biochem Labs
N-(2-phenylethyl)piperidine-4-carboxamide 95%
5 g
$ 900.00

Total 6 raw suppliers

Chemical Property of N-(2-phenylethyl)piperidine-4-carboxamide

Chemical Property:

Vapor Pressure:3.13E-08mmHg at 25°C
Boiling Point:448.3°C at 760 mmHg
Flash Point:177.9°C
PSA：41.13000
Density:1.057g/cm³
LogP:2.06460
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:232.157563266
Heavy Atom Count:17
Complexity:230

Purity/Quality:

95% ^*data from raw suppliers

N-(2-PHENYLETHYL)PIPERIDINE-4-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1C(=O)NCCC2=CC=CC=C2

Technology Process of N-(2-phenylethyl)piperidine-4-carboxamide

There total 7 articles about N-(2-phenylethyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 757949-32-9
N-(tert-butoxycarbonyl)-4-(4-phenylethyl-amidoacetyl)piperidine

: 37978-09-9
N-phenethylpiperidine-4-carboxamide

Guidance literature:: With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.11.013

Reference yield:

: 350717-33-8
4-phenethylcarbamoyl-piperidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester

: 37978-09-9
N-phenethylpiperidine-4-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;
DOI:10.1021/jo010111w

Reference yield:

: 498-94-2
isonipecotic acid

: 37978-09-9
N-phenethylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / triethylamine / tetrahydrofuran; H₂O / 20 °C

2: 81 percent / EDCI; HOBt; Et₃N / CHCl₃; dimethylformamide / 16 h / 20 °C

3: TFA / CH₂Cl₂ / 2.5 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jo010111w