Chemical Property of Piperlongumine
Chemical Property:
- Melting Point:124oC
- Boiling Point:475.6°Cat760mmHg
- PKA:-1.88±0.20(Predicted)
- Flash Point:241.4°C
- PSA：65.07000
- Density:1.223g/cm3
- LogP:1.97860
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥5mg/mL at warmed to 60°C
- XLogP3:2.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:317.12632271
- Heavy Atom Count:23
- Complexity:473
- Purity/Quality:
-
98% *data from raw suppliers
Piperlongumine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O
- Isomeric SMILES:COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O
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Description
A piperidinone alkaloid present in Piper longum, the structure has been shown
to be N-(3:4:5-trimethoxycinnamoyl)-Lls-piperidin-2-one. In the plant, the base
occurs mainly in the roots.
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Uses
Piperlongumine has been used to study the regulation of protein regulator of cytokinesis 1 (PRC1) expression. It has also been used to investigate its anti-tumor effects on human melanoma cells in vitro. Piperlongumine (PL), a new alkaloid abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. It may have anti-cancer properties. It selectively targets and kills cancer cells but leaving normal cells unharmed. anti-asthma, antibronchitis
