2-AMINOMETHYL-ADAMANTAN-2-OL

Base Information

• Chemical Name: 2-AMINOMETHYL-ADAMANTAN-2-OL
• CAS No.: 28529-71-7
• Molecular Formula: C11H19 N O
• Molecular Weight: 181.278
• Hs Code.: 2922199090
• Mol file: 28529-71-7.mol

Synonyms:2-Adamantanol,2-(aminomethyl)- (8CI); 2-Aminomethyl-2-adamantanol; NSC 145166

Chemical Property of 2-AMINOMETHYL-ADAMANTAN-2-OL

Chemical Property:

• Vapor Pressure: 0.000118mmHg at 25°C
• Boiling Point: 299.6°Cat760mmHg
• Flash Point: 135°C
• PSA: 46.25000
• Density: 1.135g/cm³
• LogP: 1.83260

Purity/Quality:

99% ^*data from raw suppliers

2-(aminomethyl)-2-adamantanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINOMETHYL-ADAMANTAN-2-OL

There total 5 articles about 2-AMINOMETHYL-ADAMANTAN-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-cyanoadamantan-2-ol (24779-92-8) → (1r,3r,5r,7r)‐2‐(aminomethyl)adamantan‐2‐ol (28529-71-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1016/j.ejmech.2010.08.009

Reference yield: 92.0%

2-cyanoadamantan-2-ol (24779-92-8) → 1-adamantanol (700-57-2) + (1r,3r,5r,7r)‐2‐(aminomethyl)adamantan‐2‐ol (28529-71-7)

Guidance literature:

With sodium tetrahydroborate; hydrogen; nickel dichloride; In tert-butyl alcohol; at 70 ℃; for 12h; under 760.051 Torr;

DOI:10.1134/S1070363216020110

Reference yield:

2-Adamantanone (700-58-3) + trimethylsilyl cyanide (7677-24-9) → (1r,3r,5r,7r)‐2‐(aminomethyl)adamantan‐2‐ol (28529-71-7)

Guidance literature:

2-Adamantanone; trimethylsilyl cyanide; With zinc(II) iodide; In dichloromethane; at 20 ℃; for 24h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 70 ℃; for 5h;

upstream raw materials:

2-cyanoadamantan-2-ol

2-Adamantanone

trimethylsilyl cyanide

Downstream raw materials:

N-(2-hydroxy-2-tricyclo[3.3.1.1.(3,7)]decylmethyl)benzamide

adamantane-spiro-5-oxazolidin-2-one

adamantane-spiro-5-<(N-m-nitrobenzoyl)oxazolidin-2-one>

homoadamantan-4-one

Refernces

• 1、 Popov,Mokhov,Tankabekyan. "Condensation of adamantanone with methylene-active compounds". . p. 404 - 409. Retrieved 2013/07/04.
• 2、 -. "PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS". Page/Page column 158-159. . Retrieved 2009/06/27.