2,5-Diacetylaminoanisole

Base Information

• Chemical Name: 2,5-Diacetylaminoanisole
• CAS No.: 51837-64-0
• Molecular Formula: C11H13NO3
• Molecular Weight: 222.244
• DSSTox Substance ID: DTXSID30966165
• Wikidata: Q82948527
• Mol file: 51837-64-0.mol

Synonyms:2,5-Diacetylaminoanisole;51837-64-0;CCRIS 1982;DTXSID30966165;2,5-diacetylamino-1-methoxybenzene;AKOS005216272;LS-188611;N-[4-(acetylamino)-2-methoxyphenyl]acetamide;N,N'-(2-Methoxy-1,4-phenylene)diethanimidato

Chemical Property of 2,5-Diacetylaminoanisole

Chemical Property:

• Vapor Pressure: 4.12E-07mmHg at 25°C
• Boiling Point: 415.5°Cat760mmHg
• Flash Point: 205.1°C
• Density: 1.159g/cm³
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 222.10044231
• Heavy Atom Count: 16
• Complexity: 268

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC(=C(C=C1)NC(=O)C)OC

Technology Process of 2,5-Diacetylaminoanisole

There total 1 articles about 2,5-Diacetylaminoanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methoxy-1,4-phenylenediamine (5307-02-8) + acetic anhydride (108-24-7) → N,N'-(methoxy-p-phenylene)-bis-acetamide (51837-64-0)

Guidance literature:

In pyridine; at 0 ℃; for 1h;

DOI:10.1055/s-1997-956

Reference yield:

N,N'-(methoxy-p-phenylene)-bis-acetamide (51837-64-0) → phanquinone (84-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) sodium 2-nitrobenzenesulfate, FeSO₄*7H₂O, H₂SO₄, 2) H₂SO₄ / 1) 98 deg C, 1 h then 140 deg C, 1 h, 2) 70 - 90 deg C then 133 deg C, 4 h

2: 82 percent / 96percent H₂SO₄, 90percent HNO₃ / 2 h / 96 °C

With sulfuric acid; nitric acid; sodium o-nitrobenzenesulfonate;

DOI:10.1055/s-1997-956

Reference yield:

N,N'-(methoxy-p-phenylene)-bis-acetamide (51837-64-0) → 2-methoxy-1,4-phenylenediamine (5307-02-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1039/c2ra22292b

upstream raw materials:

2-methoxy-1,4-phenylenediamine

acetic anhydride

Downstream raw materials:

N,N'-(2-methoxy-5-nitro-p-phenylene)-bis-acetamide

5-methoxy-[4,7]phenanthroline

phanquinone

2-methoxy-1,4-phenylenediamine