4,5-dichloro-N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-oxoethyl]-N-(4-ethoxyphenyl)-1,2-thiazole-3-carboxamide

Base Information

Chemical Name:4,5-dichloro-N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-oxoethyl]-N-(4-ethoxyphenyl)-1,2-thiazole-3-carboxamide
CAS No.:3907-03-7
Molecular Formula:C25H24Cl2FN3O3S
Molecular Weight:536.4458
Hs Code.:
DSSTox Substance ID:DTXSID40390412

Synonyms:3907-03-7;Oprea1_090460;Oprea1_422030;DTXSID40390412;AKOS000680638;AKOS024309509;4,5-dichloro-N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-oxoethyl]-N-(4-ethoxyphenyl)-1,2-thiazole-3-carboxamide

Suppliers and Price of 4,5-dichloro-N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-oxoethyl]-N-(4-ethoxyphenyl)-1,2-thiazole-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5-dichloro-N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-oxoethyl]-N-(4-ethoxyphenyl)-1,2-thiazole-3-carboxamide

Chemical Property:

Vapor Pressure:1.94E-17mmHg at 25°C
Boiling Point:662.8°Cat760mmHg
Flash Point:354.7°C
Density:1.42g/cm³
XLogP3:6.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:535.0899464
Heavy Atom Count:35
Complexity:716

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC=C(C=C1)N(C(C2=CC=C(C=C2)F)C(=O)NC3CCCC3)C(=O)C4=NSC(=C4Cl)Cl

Technology Process of 4,5-dichloro-N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-oxoethyl]-N-(4-ethoxyphenyl)-1,2-thiazole-3-carboxamide

There total 6 articles about 4,5-dichloro-N-[2-(cyclopentylamino)-1-(4-fluorophenyl)-2-oxoethyl]-N-(4-ethoxyphenyl)-1,2-thiazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 22509-74-6
N-ethoxycarbonylphthalimide

: 63038-27-7,167223-43-0
L-tert-leucine methyl ester hydrochloride

: 137649-36-6,3907-03-7
N-phthaloyl-(S)-tert-leucine methyl ester

Guidance literature:: With sodium carbonate; In water;

Reference yield: 23.0%

: 85-44-9
phthalic anhydride

: 63038-26-6
(S)-2-amino-3,3-dimethyl-butyric acid methyl ester

: 137649-36-6,3907-03-7
N-phthaloyl-(S)-tert-leucine methyl ester

Guidance literature:: In 1,4-dioxane; stereoselective reaction; Inert atmosphere; Reflux;
DOI:10.1039/d0ob00052c

Reference yield:

: 20859-02-3
L-tert-Leucine

: 137649-36-6,3907-03-7
N-phthaloyl-(S)-tert-leucine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 14 percent / aq. Na₂CO₃ / 10 h / 20 °C

2: diethyl ether

With sodium carbonate; In diethyl ether;
DOI:10.1248/cpb.53.1366