L-TERT-LEUCINE METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: L-TERT-LEUCINE METHYL ESTER HYDROCHLORIDE
• CAS No.: 63038-27-7
• Molecular Formula: C7H15NO2.ClH
• Molecular Weight: 181.663
• Hs Code.: 29224999
• Mol file: 63038-27-7.mol

Synonyms:L-Valine,3-methyl-, methyl ester, hydrochloride (9CI);L-tert-Leucine methyl esterhydrochloride;Methyl (2S)-2-amino-3,3-dimethylbutanoate hydrochloride;

Chemical Property of L-TERT-LEUCINE METHYL ESTER HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: White to off-white powder
• Vapor Pressure: 0.195mmHg at 25°C
• Melting Point: 183-186 °C
• Refractive Index: 16.5 ° (C=1, MeOH)
• Boiling Point: 206.8 °C at 760 mmHg
• Flash Point: 78.9 °C
• PSA: 52.32000
• LogP: 2.03510
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

min 98.0% ^*data from raw suppliers

L-tert-Leucine Methyl Ester Hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-tert-Leucine Methyl Ester Hydrochloride is used in the preparation of peptidomimetic protease inhibitors.

Technology Process of L-TERT-LEUCINE METHYL ESTER HYDROCHLORIDE

There total 10 articles about L-TERT-LEUCINE METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + L-tert-Leucine (20859-02-3) → L-tert-leucine methyl ester hydrochloride (63038-27-7,167223-43-0)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

DOI:10.1002/anie.201902513

Reference yield: 76.0%

methanol (67-56-1) + N-tert-butyloxycarbonyl-L-tert-leucine (62965-35-9) → L-tert-leucine methyl ester hydrochloride (63038-27-7,167223-43-0)

Guidance literature:

With thionyl chloride; at 0 - 80 ℃; for 8h; Inert atmosphere;

Reference yield: 52.0%

methanol (67-56-1) + t-butoxycarbonyl-L-t-butylglycine dicyclohexylamine salt → L-tert-leucine methyl ester hydrochloride (63038-27-7,167223-43-0)

Guidance literature:

With thionyl chloride; at 40 ℃;

DOI:10.1002/hlca.19800630410

upstream raw materials:

methanol

L-tert-Leucine

2-<(S)-α-methylbenzylamino>-3,3,dimethylbutyramide

pivalaldehyde

Downstream raw materials:

methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3,3-dimethyl]butanoate

C₂₀H₂₀ClF₃N₂O₃

(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3,3-dimethylbutanoic acid

2-(benzyloxy)-5-chloro-N-[(2S)-3,3-dimethyl-1-oxo-1-[[3-(trifluoromethyl)phenyl]amino]butan-2-yl]benzamide

Refernces

• 1、 Stress, Cedric J.,Sauter, Basilius,Schneider, Lukas A.,Sharpe, Timothy,Gillingham, Dennis. "A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles". supporting information. p. 9570 - 9574. Retrieved 2019/06/24.
• 2、 Stefanucci, Azzurra,Macedonio, Giorgia,Dvorácskó, Szabolcs,T?mb?ly, Csaba,Mollica, Adriano. "Novel Fubinaca/Rimonabant hybrids as endocannabinoid system modulators". . p. 1595 - 1605. Retrieved 2018/09/14.