5-(4-Amino-3-methoxybenzyl)-2,4-thiazolidinedione

Base Information

Chemical Name:5-(4-Amino-3-methoxybenzyl)-2,4-thiazolidinedione
CAS No.:86733-81-5
Molecular Formula:C11H12N2O3S
Molecular Weight:252.2896
Hs Code.:
DSSTox Substance ID:DTXSID101007068
Nikkaji Number:J59.616G
Mol file:86733-81-5.mol

Synonyms:5-(4-Amino-3-methoxybenzyl)-2,4-thiazolidinedione;86733-81-5;BRN 5549627;2,4-Thiazolidinedione, 5-(4-amino-3-methoxybenzyl)-;2,4-Thiazolidinedione, 5-((4-amino-3-methoxyphenyl)methyl)-;SCHEMBL15065437;DTXSID101007068;LS-151289;5-[(4-Amino-3-methoxyphenyl)methyl]-4-hydroxy-1,3-thiazol-2(5H)-one

Suppliers and Price of 5-(4-Amino-3-methoxybenzyl)-2,4-thiazolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-(4-AMINO-3-METHOXYBENZYL)-2,4-THIAZOLIDINEDIONE 95.00%
5MG
$ 496.16

Total 3 raw suppliers

Chemical Property of 5-(4-Amino-3-methoxybenzyl)-2,4-thiazolidinedione

Chemical Property:

Vapor Pressure:1.48E-09mmHg at 25°C
Boiling Point:484.9°Cat760mmHg
Flash Point:247°C
PSA：106.72000
Density:1.387g/cm³
LogP:2.08150
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:252.05686342
Heavy Atom Count:17
Complexity:324

Purity/Quality:: 5-(4-AMINO-3-METHOXYBENZYL)-2,4-THIAZOLIDINEDIONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)CC2C(=O)NC(=O)S2)N

Technology Process of 5-(4-Amino-3-methoxybenzyl)-2,4-thiazolidinedione

There total 3 articles about 5-(4-Amino-3-methoxybenzyl)-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.7%

: 86733-95-1
5-(4-acetamido-3-methoxybenzyl)-2-iminothiazolidin-4-one

: 86733-81-5
5-(4-amino-3-methoxybenzyl)thiazolidine-2,4-dione

Guidance literature:: With hydrogenchloride; In ethanol; for 20h;
DOI:10.1248/cpb.31.560

Reference yield:

: 86726-33-2
3-(4-Acetylamino-3-methoxy-phenyl)-2-chloro-propionic acid methyl ester

: 86733-81-5
5-(4-amino-3-methoxybenzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 57.5 percent / AcONa / 2-methoxy-ethanol / 16 h / 100 °C

2: 64.7 percent / 6N HCl / ethanol / 20 h

With hydrogenchloride; sodium acetate; In ethanol; 2-methoxy-ethanol;
DOI:10.1248/cpb.31.560

Reference yield:

: 5329-15-7
N-(4-amino-2-methoxyphenyl)acetamide

: 86733-81-5
5-(4-amino-3-methoxybenzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) H₂O, acetone, 5 deg C, 15 min, 2.) H₂O, acetone, 5 -> 35 deg C

2: 57.5 percent / AcONa / 2-methoxy-ethanol / 16 h / 100 °C

3: 64.7 percent / 6N HCl / ethanol / 20 h

With copper(I) oxide; hydrogenchloride; sodium acetate; sodium nitrite; In ethanol; 2-methoxy-ethanol;
DOI:10.1248/cpb.31.560