5-(4-methoxyphenyl)pentanoic acid

Base Information

• Chemical Name: 5-(4-methoxyphenyl)pentanoic acid
• CAS No.: 7508-04-5
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Hs Code.: 2918990090
• Mol file: 7508-04-5.mol

Synonyms:5-(4-Methoxy-phenyl)-valeriansaeure;5-(4-methoxyphenyl)-pentanoic acid;5-(4-methoxy-phenyl)-valeric acid;5--valeriansaeure;

Chemical Property of 5-(4-methoxyphenyl)pentanoic acid

Chemical Property:

• Vapor Pressure: 3.55E-06mmHg at 25°C
• Boiling Point: 371.5°Cat760mmHg
• Flash Point: 142.3°C
• PSA: 46.53000
• Density: 1.093g/cm³
• LogP: 2.49260

Purity/Quality:

99%min ^*data from raw suppliers

5-(4-METHOXY-PHENYL)-PENTANOIC ACID AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-methoxyphenyl)pentanoic acid

There total 28 articles about 5-(4-methoxyphenyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-(4-methoxyphenyl)-5-oxopentanoic acid (4609-10-3) → 5-(4-methoxyphenyl)pentanoic acid (7508-04-5)

Guidance literature:

With hydrogen; acetic acid; palladium 10% on activated carbon; In ethanol; at 20 ℃;

Reference yield: 88.0%

5-(4-methoxyphenyl)pentanoic acid ethyl ester (79023-06-6) → 5-(4-methoxyphenyl)pentanoic acid (7508-04-5)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 12h;

DOI:10.1016/j.bmc.2013.07.010

Reference yield: 85.0%

carbon dioxide (124-38-9,18923-20-1) + 1-(4-chlorobutyl)-4-methoxybenzene (23002-61-1) → 5-(4-methoxyphenyl)pentanoic acid (7508-04-5)

Guidance literature:

With nickel(II) bromide dimethoxyethane; manganese; 2,9-dibutyl-4,7-dimethyl-1,10-phenanthroline; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 60 ℃; under 760.051 Torr; Reagent/catalyst; Solvent; Schlenk technique;

DOI:10.1021/jacs.6b04088

upstream raw materials:

5-(4-methoxyphenyl)-5-oxopentanoic acid

[3-(4-methoxy-phenyl)-propyl]-malonic acid

5-(4'-hydroxyphenyl)pentanoic acid

dimethyl sulfate

Downstream raw materials:

1,1,1,2,2-pentafluoro-7-(4-methoxyphenyl)heptan-3-one

ethyl 5-(4-(hydroxyl)phenyl)pentanoate

5-(4-methoxy-phenyl)-5-oxo-pentanoic acid methyl ester

Refernces

• 1、 Pandey, Ganesh,Laha, Ramkrishna,Mondal, Pradip Kumar. "Heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis". . p. 9689 - 9692. Retrieved 2019/08/15.
• 2、 Tan, Haibo,Liu, Hongxin,Chen, Xinzheng,Chen, Huiyu,Qiu, Shengxiang. "Racemic total synthesis of dactyloidin and demethyldactyloidin through the dl-proline-catalyzed Knoevenagel condensation/[4 + 2] cycloaddition cascade". supporting information. p. 9977 - 9983. Retrieved 2015/10/12.