6-Dfcmh

Base Information

• Chemical Name: 6-Dfcmh
• CAS No.: 99552-37-1
• Molecular Formula: C₄₂H₆₉FO₃₄
• Molecular Weight: 1136.99
• Mol file: 99552-37-1.mol

Synonyms:6-deoxy-6-fluorocyclomaltoheptaose;6-DFCMH;mono-6-deoxy-6-fluorocyclomaltoheptaose

Chemical Property of 6-Dfcmh

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1516.6°Cat760mmHg
• Flash Point: 496.3°C
• PSA: 533.82000
• Density: 1.608g/cm³
• LogP: -14.25340
• XLogP3: -14
• Hydrogen Bond Donor Count: 20
• Hydrogen Bond Acceptor Count: 35
• Rotatable Bond Count: 7
• Exact Mass: 1136.3654274
• Heavy Atom Count: 77
• Complexity: 1840

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(O2)C(C8O)O)CO)CO)CO)CF)CO)CO)O)O)O
• Isomeric SMILES: C([C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](OC([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]8[C@H](O[C@H](O2)[C@@H]([C@H]8O)O)CO)CO)CO)CO)CF)CO)O)O)O

Technology Process of 6-Dfcmh

There total 2 articles about 6-Dfcmh which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(2,3-di-O-acetyl-6-deoxy-6-fluoro)hexakis(2,3,6-tri-O-acetyl)cyclomaltoheptaose → (6-deoxy-6-fluoro)hexakiscyclomaltoheptaose (99552-37-1)

Guidance literature:

With sodium methylate; In methanol; Ambient temperature;

DOI:10.1080/07328309908543991

Reference yield:

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin (67217-55-4) → (6-deoxy-6-fluoro)hexakiscyclomaltoheptaose (99552-37-1)

Guidance literature:

With potassium fluoride; In ethylene glycol; for 0.05h; Heating;

DOI:10.1016/S0008-6215(00)90700-6

Reference yield:

(6-deoxy-6-fluoro)hexakiscyclomaltoheptaose (99552-37-1) → 6-fluoro-6-deoxyglucosse (4536-08-7) + 4-O-(6'-deoxy-6'-fluoro-α-D-glucopyranosyl)-β-D-glucopyranoside + 4-O-(α-D-glucopyranosyl)-6-deoxy-6-fluoro-β-D-glucopyranoside

Guidance literature:

With porcine-pancreatic alpha amylase; water; at 37 ℃; for 120h; Product distribution; buffer (sodium glycerophosphate, NaCl, NaN3), pH = 6.9; product analysis by radiotracer techniques after reduction with <3H> borohydride;

DOI:10.1016/S0008-6215(00)90700-6

upstream raw materials:

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin

Downstream raw materials:

D-glucose

6-fluoro-6-deoxyglucosse

Refernces

• 1、 Braun,French,Robyt. "Porcine-pancreatic alpha amylase hydrolysis of substrates containing 6-deoxy-D-glucose and 6-deoxy-6-fluoro-D-glucose and the specificity of subsite binding.". . p. 107 - 116. Retrieved 2007/10/02.