5H-Pyrido[1,2-c]pyrrolo[1,2-a]pyrimidine,decahydro-5-pentyl-, (5S,6aR,11aS)-

Base Information

• Chemical Name: 5H-Pyrido[1,2-c]pyrrolo[1,2-a]pyrimidine,decahydro-5-pentyl-, (5S,6aR,11aS)-
• CAS No.: 109269-89-8
• Molecular Formula: C16H30 N2
• Molecular Weight: 250.428
• Mol file: 109269-89-8.mol

Synonyms:5H-Pyrido[1,2-c]pyrrolo[1,2-a]pyrimidine,decahydro-5-pentyl-, [5S-(5a,6ab,11ab)]-; (+)-Tetraponerine 8; Tetraponerine 8

Chemical Property of 5H-Pyrido[1,2-c]pyrrolo[1,2-a]pyrimidine,decahydro-5-pentyl-, (5S,6aR,11aS)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5H-Pyrido[1,2-c]pyrrolo[1,2-a]pyrimidine,decahydro-5-pentyl-, (5S,6aR,11aS)-

There total 2 articles about 5H-Pyrido[1,2-c]pyrrolo[1,2-a]pyrimidine,decahydro-5-pentyl-, (5S,6aR,11aS)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrrolidine (123-75-1) + 2,3,4,5-tetrahydropyridine (505-18-0) + n-pentyl methyl ketone (110-43-0) → C16H30N2 + (2R*,7R*,9S*)-7-pentyl-1,6-diazatricyclo[7.4.0.02,6]tridecane (109269-89-8,114530-39-1,116839-71-5)

Guidance literature:

2,3,4,5-tetrahydropyridine; n-pentyl methyl ketone; With rac-Pro-OH; In benzonitrile; for 168h; Inert atmosphere;

With di-tert-butyl dicarbonate; triethylamine; at 0 - 20 ℃; for 12h;

pyrrolidine; Overall yield = 32%; Overall yield = 40 mg; chemoselective reaction;

DOI:10.1002/chem.201504845

Reference yield:

pyrrolidine (123-75-1) + 2,3,4,5-tetrahydropyridine (505-18-0) + n-pentyl methyl ketone (110-43-0) → (5S,6aR,11aS)-5-pentyldecahydro-5H-pyrido[1,2-c]pyrrolo-[1,2-a]pyrimidine (109269-89-8) + (5R,6aR,11aS)-5-pentyldecahydro-5H-pyrido[1,2-c]pyrrolo-[1,2-a]pyrimidine

Guidance literature:

2,3,4,5-tetrahydropyridine; n-pentyl methyl ketone; With D-Prolin; In benzonitrile; for 168h; Inert atmosphere;

With di-tert-butyl dicarbonate; triethylamine; at 0 - 20 ℃; for 12h;

pyrrolidine; Overall yield = 32%; Overall yield = 40 mg; chemoselective reaction;

DOI:10.1002/chem.201504845

upstream raw materials:

pyrrolidine

2,3,4,5-tetrahydropyridine

n-pentyl methyl ketone

Refernces