5-Bromo-4-chloro-7-pentofuranosyl-7h-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:5-Bromo-4-chloro-7-pentofuranosyl-7h-pyrrolo[2,3-d]pyrimidine
CAS No.:24385-15-7
Molecular Formula:C₁₁H₁₁BrClN₃O₄
Molecular Weight:364.583
Hs Code.:
NSC Number:103803
DSSTox Substance ID:DTXSID00947249
Mol file:24385-15-7.mol

Synonyms:NSC103803;5-bromo-4-chloro-7-pentofuranosyl-7h-pyrrolo[2,3-d]pyrimidine;DTXSID00947249;NSC-103803

Suppliers and Price of 5-Bromo-4-chloro-7-pentofuranosyl-7h-pyrrolo[2,3-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 5-Bromo-4-chloro-7-pentofuranosyl-7h-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Vapor Pressure:7.31E-17mmHg at 25°C
Boiling Point:632.4°C at 760 mmHg
Flash Point:336.3°C
Density:2.21g/cm³
XLogP3:0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:362.96215
Heavy Atom Count:20
Complexity:369

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C2=C(N1C3C(C(C(O3)CO)O)O)N=CN=C2Cl)Br

Technology Process of 5-Bromo-4-chloro-7-pentofuranosyl-7h-pyrrolo[2,3-d]pyrimidine

There total 4 articles about 5-Bromo-4-chloro-7-pentofuranosyl-7h-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 624727-82-8
5-bromo-4-chloro-7-(5-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine

: 164514-17-4,24385-15-7
5-bromo-4-chloro-7-(α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 0.5h;
DOI:10.1021/jm030230z

Reference yield: 53.0%

: 952429-11-7
(2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diyl dibenzoate

: 24385-15-7
(2R,3R,4S,5R)-2-(5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Guidance literature:: With ammonia; In methanol; dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 22276-95-5
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 164514-17-4,24385-15-7
5-bromo-4-chloro-7-(α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: KOH; TDA-1 / toluene / 20 °C

2: 66 percent / aq. TFA / 0.5 h / 20 °C

With potassium hydroxide; trifluoroacetic acid; In toluene;
DOI:10.1021/jm030230z