952429-11-7Relevant articles and documents
Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex
D'Errico, Stefano,Oliviero, Giorgia,Borbone, Nicola,Di Gennaro, Elena,Zotti, Andrea Ilaria,Budillon, Alfredo,Cerullo, Vincenzo,Nici, Fabrizia,Mayol, Luciano,Piccialli, Vincenzo,Piccialli, Gennaro
, p. 7550 - 7556 (2015)
Herein, the synthesis of a nucleoside platinum(II) complex in which a cisplatin-like unit is joined to 7-deazaadenosine through an amino alkyl chain installed at the C6 position of purine was explored. The capability of the new complex to react with DNA p
C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents
Hulpia, Fabian,Bouton, Jakob,Campagnaro, Gustavo D.,Alfayez, Ibrahim A.,Mabille, Dorien,Maes, Louis,de Koning, Harry P.,Caljon, Guy,Van Calenbergh, Serge
, (2020/01/13)
African trypanosomiasis, a deadly infectious disease caused by the protozoan Trypanosoma brucei spp., is spread to new hosts by bites of infected tsetse flies. Currently approved therapies all have their specific drawbacks, prompting a search for novel th
Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3′,5′-cyclic monophosphate derivatives
Lelle, Marco,Otte, Maik,Thon, Susanne,Bertinetti, Daniela,Herberg, Friedrich W.,Benndorf, Klaus
, p. 1704 - 1713 (2019/03/17)
Synthetic derivatives of cyclic adenosine monophosphate, such as halogenated or other more hydrophobic analogs, are widely used compounds, to investigate diverse signal transduction pathways of eukaryotic cells. This inspired us to develop cyclic nucleoti