Oxazolo(4,5-b)pyridin-2(3H)-one, 3-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-

Base Information

Chemical Name:Oxazolo(4,5-b)pyridin-2(3H)-one, 3-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-
CAS No.:134337-01-2
Molecular Formula:C19H22N4O3
Molecular Weight:354.403
Hs Code.:
DSSTox Substance ID:DTXSID40158655
Nikkaji Number:J528.058C
Wikidata:Q83026963
ChEMBL ID:CHEMBL146582
Mol file:134337-01-2.mol

Synonyms:3-(2-(4-(2-Methoxyphenyl)-1-piperazinyl)ethyl)oxazolo(4,5-b)pyridin-2(3H)-one;Oxazolo(4,5-b)pyridin-2(3H)-one, 3-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-;134337-01-2;3-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]oxazolo[4,5-b]pyridin-2(3H)-one;CHEMBL146582;SCHEMBL9647687;DTXSID40158655;LS-100909

Suppliers and Price of Oxazolo(4,5-b)pyridin-2(3H)-one, 3-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Oxazolo(4,5-b)pyridin-2(3H)-one, 3-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-

Chemical Property:

Vapor Pressure:7.72E-12mmHg at 25°C
Boiling Point:542.7°Cat760mmHg
Flash Point:282°C
Density:1.262g/cm³
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:354.16919058
Heavy Atom Count:26
Complexity:483

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1N2CCN(CC2)CCN3C4=C(C=CC=N4)OC3=O

Technology Process of Oxazolo(4,5-b)pyridin-2(3H)-one, 3-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-

There total 4 articles about Oxazolo(4,5-b)pyridin-2(3H)-one, 3-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 134336-95-1
3-(2-bromoethyl)oxazolo<4,5-b>pyridin-2(3H)-one

: 134337-01-2
3-<2-<4-(2-methoxyphenyl)-1-piperazinyl>ethyl>oxazolo<4,5-b>pyridin-2(3H)-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 60 ℃; for 12h;
DOI:10.1021/jm00056a010

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 134337-01-2
3-<2-<4-(2-methoxyphenyl)-1-piperazinyl>ethyl>oxazolo<4,5-b>pyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / tetrahydrofuran / 6 h / Heating

2: 1.) EtONa / 1.) EtOH, RT, 1 h, 2.) DMF, 110 deg C, 1 h

3: 96 percent / diisopropylethylamine / acetonitrile / 12 h / 60 °C

With sodium ethanolate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00056a010

Reference yield:

: 60832-72-6
2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one

: 134337-01-2
3-<2-<4-(2-methoxyphenyl)-1-piperazinyl>ethyl>oxazolo<4,5-b>pyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) EtONa / 1.) EtOH, RT, 1 h, 2.) DMF, 110 deg C, 1 h

2: 96 percent / diisopropylethylamine / acetonitrile / 12 h / 60 °C

With sodium ethanolate; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1021/jm00056a010